About: A genetic analysis of macrophage activation and specific antibodies in relation to the resistance of heterogeneous mouse populations to MHV3 infection

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About: A genetic analysis of macrophage activation and specific antibodies in relation to the resistance of heterogeneous mouse populations to MHV3 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A genetic analysis of macrophage activation and specific antibodies in relation to the resistance of heterogeneous mouse populations to MHV3 infection
Creator	Pereira, C Vassfio, R Sant' Anna, O
source	PMC
abstract	The genetically selected high antibody responder mice (H(III)) are susceptible and the low antibody responder mice (L(III)) are resistant to the experimental infection with Mouse Hepatitis Virus 3 (MHV3). The mortality rates of the F(1) hybrids and of the F(2) segregants showed the codominance of the susceptible and resistant characters. The direct individual intrapopulation correlation between the induction of antiviral state in macrophages activated by IFN gamma and the resistance to the virus infection, showed that an antiviral state could be induced in resistant mouse macrophages, whereas in susceptible mouse macrophages no restriction of virus replication could be observed. A direct inter- and intrapopulation correlation of pre-existing antibody titres against MHV3 with the mortality and a direct interpopulation correlation of those titres with the mean survival time of susceptible animals was shown. The data indicate, among the mechanisms of resistance against the virus infection, a role of IFN gamma macrophage-activation and of antibodies against MHV3 which may delay the mean survival time in susceptible animals.
has issue date	1994-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01310802
bibo:pmid	7832646
has license	no-cc
sha1sum (hex)	bb8206c6c191651b94841df3e6e4599b62fb4f23
schema:url	https://doi.org/10.1007/bf01310802
resource representing a document's title	A genetic analysis of macrophage activation and specific antibodies in relation to the resistance of heterogeneous mouse populations to MHV3 infection
has PubMed Central identifier	PMC7086603
has PubMed identifier	7832646
schema:publication	Arch Virol
resource representing a document's body	covid:bb8206c6c191651b94841df3e6e4599b62fb4f23#body_text
is schema:about of	named entity 'codominance' named entity 'individual' named entity 'mortality rates' named entity 'correlation' named entity 'data' named entity 'activation' named entity 'RESISTANCE' covid:arg/bb8206c6c191651b94841df3e6e4599b62fb4f23 named entity 'CHARACTERS' named entity 'SELECTED' named entity 'ANTIBODIES' named entity 'MOUSE' named entity 'INDIVIDUAL' named entity 'PRE-EXISTING' named entity 'CORRELATION' named entity 'CODOMINANCE' named entity 'VIRUS INFECTION' named entity 'MACROPHAGE ACTIVATION' named entity 'POPULATIONS' named entity 'RESISTANT TO' named entity 'ANTIBODY TITRES' named entity 'LOW' named entity 'INTER-' named entity 'MOUSE HEPATITIS VIRUS' named entity 'INDUCED' named entity 'INDUCTION' named entity 'VIRUS REPLICATION' named entity 'ANTIBODY' named entity 'HETEROGENEOUS' named entity 'ANTIVIRAL' named entity 'RESISTANCE' named entity 'ANIMALS' named entity 'NO RESTRICTION' named entity 'RESISTANT' named entity 'MOUSE' named entity 'RELATION' named entity 'GENETIC ANALYSIS' named entity 'INFECTION' named entity 'MORTALITY RATES' named entity 'MEAN SURVIVAL TIME' named entity 'SPECIFIC' named entity 'ANTIBODIES' named entity 'DIRECT' named entity 'MECHANISMS' named entity 'ROLE' named entity 'MACROPHAGE' named entity 'MICE' named entity 'DATA' named entity 'HYBRIDS' named entity 'SUSCEPTIBLE' named entity 'STATE' named entity 'IFN GAMMA' named entity 'DELAY' named entity 'ACTIVATED' named entity 'EXPERIMENTAL INFECTION' named entity 'ACTIVATION' named entity 'MACROPHAGES' named entity 'COULD BE' named entity 'MORTALITY' named entity 'RESISTANCE TO' named entity 'OBSERVED' named entity 'HIGH' named entity 'direct' named entity 'virus' named entity 'titres' named entity 'time' named entity 'mice' named entity 'correlation' named entity 'macrophages' named entity 'antiviral' named entity 'mice' named entity 'survival time' named entity 'antiviral' named entity 'antibody titres' named entity 'correlation' named entity 'antibodies' named entity 'Mouse Hepatitis Virus' named entity 'rabies virus' named entity 'macrophages'

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