About: Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat
Creator	Jacob, Howard Kwitek, Anne Lander, Eric Lernmark, Ke Macmurray, Armand Moralejo, Daniel Park, Hyunhee Speros, Sara
Source	Elsevier; Medline; PMC
abstract	Abstract Peripheral T cell lymphopenia (lyp) in the BioBreeding (BB) rat is linked to a frameshift mutation in Ian5, a member of the Immune Associated Nucleotide (Ian) gene family on rat chromosome 4. This lymphopenia leads to type 1 (insulin-dependent) diabetes mellitus (T1DM) at rates up to 100% when combined with the BB rat MHC RT1 u/u genotype. In order, to better study the lymphopenia phenotype without possible confounding effects of diabetes or other autoimmune disease, we generated congenic F344.lyp rats by introgression of lyp on diabetes-resistant MHC RT1 lv1/lv1 F344 rats. Analysis of thymic CD4 and CD8 T lymphocytes revealed no difference in the percentage of CD4−CD8+and CD4+CD8−subsets in lyp/lyp compared to +/+ F344 rats. The same subsets was however dramatically reduced in blood (P=0.005), spleen (P=0.019) and mesenteric lymph nodes (MLN) (P<0.0001). Compared to F344 +/+ rats double positive CD4+CD8+T cells were increased only in lyp/lyp spleen (P=0.034) while double negative CD4−CD8−were increased in thymus (P=0.033), spleen (P=0.012), MLN (P<0.0001), and peripheral blood (P<0.0001). There were no signs of inflammatory lesions in organs and tissues in F344.lyp/lyp rats examined at 120 days of age or older. We thus conclude that the lymphopenia phenotype was reconstituted by introgression of lyp on to F344 rats without subsequent development of organ-specific autoimmunity. The congenic F344.lyp rat should prove useful to dissect the mechanisms by which the Ian5 frameshift mutation affects T cell selection, differentiation and maturation without organ-specific autoimmunity.
has issue date	2003-12-31(xsd:dateTime)
bibo:doi	10.1016/s0896-8411(03)00138-0
bibo:pmid	14624755
has license	els-covid
sha1sum (hex)	bbed2ab18cb16dd893636d982a873f73f3550605
schema:url	https://doi.org/10.1016/s0896-8411%2803%2900138-0
resource representing a document's title	Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat
has PubMed Central identifier	PMC7126882
has PubMed identifier	14624755
schema:publication	Journal of Autoimmunity
resource representing a document's body	covid:bbed2ab18cb16dd893636d982a873f73f3550605#body_text
is schema:about of	named entity 'T lymphocytes' named entity 'subsets' named entity 'signs' named entity 'spleen' named entity 'lyp' named entity 'rats' named entity 'autoimmunity' named entity 'RAT' named entity 'ASSOCIATED' named entity 'T CELL SELECTION' named entity 'POSSIBLE' named entity 'PERCENTAGE' named entity 'PERIPHERAL' named entity 'TYPE 1' named entity 'LYP' named entity 'DEVELOPMENT' named entity 'POSITIVE' named entity 'DIABETES MELLITUS' named entity 'EXAMINED' named entity 'T CELL' named entity 'USEFUL' named entity 'DISSECT' named entity 'PHENOTYPE' named entity 'ORDER' named entity 'DEPENDENT' named entity 'SUBSEQUENT' named entity 'SPECIFIC' named entity '120' named entity 'CONCLUDE' named entity 'BETTER' named entity 'AGE' named entity 'COMBINED' named entity 'NO DIFFERENCE' named entity 'INFLAMMATORY' named entity 'EFFECTS' named entity 'CD4' named entity '012' named entity 'RECONSTITUTED' named entity 'LYMPHOPENIA' named entity 'NEGATIVE' named entity 'DIFFERENTIATION' named entity 'F344' named entity 'THYMUS' named entity 'MESENTERIC LYMPH NODES' named entity 'SIGNS' named entity 'T CELLS' named entity 'MEMBER OF' named entity 'IMMUNE' named entity 'REVEALED' named entity 'GENE' named entity 'CD4 CD8' named entity 'CD8 T LYMPHOCYTES' named entity 'RESISTANT' named entity 'RAT' named entity 'PERIPHERAL BLOOD' named entity 'F344' named entity 'DAYS' named entity 'GENE FAMILY' named entity '100%' named entity 'NUCLEOTIDE' named entity 'COMPARED' covid:arg/bbed2ab18cb16dd893636d982a873f73f3550605 named entity 'DOUBLE' named entity 'ANALYSIS' named entity 'MECHANISMS' named entity 'INTROGRESSION' named entity 'ORGAN' named entity 'GENERATED' named entity 'AUTOIMMUNITY' named entity 'INTROGRESSION' named entity 'DISSECTION' named entity 'LYMPHOPENIA' named entity 'MUTATED' named entity 'INCREASED'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software