About: The pathogen receptor liver and lymph node sinusoidal endotelial cell C‐type lectin is expressed in human Kupffer cells and regulated by PU.1

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About: The pathogen receptor liver and lymph node sinusoidal endotelial cell C‐type lectin is expressed in human Kupffer cells and regulated by PU.1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The pathogen receptor liver and lymph node sinusoidal endotelial cell C‐type lectin is expressed in human Kupffer cells and regulated by PU.1
Creator	Bustos, Matilde Clária, Joan Corbí, Angel Corcuera, María Aragoneses-Fenoll, Laura García-Monzón, Carmelo Gómez-Aguado, Fernando Ngeles Domínguez-Soto, Á
source	Medline; PMC
abstract	Human LSECtin (liver and lymph node sinusoidal endothelial cell C‐type lectin, CLEC4G) is a C‐type lectin encoded within the L‐SIGN/DC‐SIGN/CD23 gene cluster. LSECtin acts as a pathogen attachment factor for Ebolavirus and the SARS coronavirus, and its expression can be induced by interleukin‐4 on monocytes and macrophages. Although reported as a liver and lymph node sinusoidal endothelial cell‐specific molecule, LSECtin could be detected in the MUTZ‐3 dendritic‐like cell line at the messenger RNA (mRNA) and protein level, and immunohistochemistry analysis on human liver revealed its presence in Kupffer cells coexpressing the myeloid marker CD68. The expression of LSECtin in myeloid cells was further corroborated through the analysis of the proximal regulatory region of the human LSECtin gene, whose activity was maximal in LSECtin+ myeloid cells, and which contains a highly conserved PU.1‐binding site. PU.1 transactivated the LSECtin regulatory region in collaboration with hematopoietic‐restricted transcription factors (Myb, RUNX3), and was found to bind constitutively to the LSECtin proximal promoter. Moreover, knockdown of PU.1 through the use of small interfering RNA led to a decrease in LSECtin mRNA levels in THP‐1 and monocyte‐derived dendritic cells, thus confirming the involvement of PU.1 in the myeloid expression of the lectin. Conclusion: LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor. (Hepatology 2009;49:287–296.)
has issue date	2008-12-18(xsd:dateTime)
bibo:doi	10.1002/hep.22678
bibo:pmid	19111020
has license	no-cc
sha1sum (hex)	bc22d40436020c8faff28e7a8a8be96c6b5ff957
schema:url	https://doi.org/10.1002/hep.22678
resource representing a document's title	The pathogen receptor liver and lymph node sinusoidal endotelial cell C‐type lectin is expressed in human Kupffer cells and regulated by PU.1
has PubMed Central identifier	PMC7165556
has PubMed identifier	19111020
schema:publication	Hepatology
resource representing a document's body	covid:bc22d40436020c8faff28e7a8a8be96c6b5ff957#body_text
is schema:about of	named entity 'activity' named entity 'cells' named entity 'PU.1' named entity 'small interfering RNA' named entity 'proximal' named entity 'induced' named entity 'C-type lectin' named entity 'Receptor' named entity 'revealed' named entity 'myeloid' named entity 'cluster' named entity 'macrophages' named entity 'sinusoidal' named entity 'human' named entity 'highly' named entity 'mRNA' named entity 'chromosome' named entity 'PU.1' named entity 'L-SIGN' named entity 'liver' named entity 'levels' named entity 'immunohistochemistry' named entity 'dependent' named entity 'Myb' named entity 'Liver' named entity 'PU.1' named entity 'HEPATOLOGY' named entity 'macrophages' named entity 'liver' named entity 'RUNX3' named entity 'gene' named entity 'pathogen' named entity 'highly conserved' named entity 'PU.1' named entity 'myeloid cells' named entity 'PU.1' named entity 'mRNA' named entity 'THP-1' named entity 'transcription factor' named entity 'myeloid' named entity 'cell line' named entity 'interleukin-4' named entity 'myeloid cells' named entity 'transcription factors' named entity 'gene cluster' named entity 'C-type lectin' named entity 'monocytes' named entity 'myeloid' named entity 'mammals' named entity 'PCR' named entity 'hepatic' named entity 'antibodies' named entity 'PU.1' named entity 'lysate' named entity 'Santa Cruz Biotechnology' named entity 'regulatory regions' named entity 'cell-cell adhesion' named entity 'regulatory region' named entity 'GAPDH' named entity 'innate response' named entity 'tissue sections' named entity 'regulatory region' named entity 'STAT6' named entity 'myeloid cells' named entity 'siRNA' named entity 'Kupffer cells' named entity 'Germany' named entity 'transcriptional activity' named entity 'immunoglobulin' named entity 'Assay' named entity 'DC-SIGN' named entity 'PU.1' named entity 'tissue staining' named entity 'DC-SIGN'

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