About: Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique
Creator	Yang, Jing Huang, Yan Wang, Dingming Yang, Lei Shu, Yuelong Wang, Dayan Zhao, Xiang Wang, Z Chen, Tao Zou, Xiaohui Chen, W Wang, D Chen, Wenbing Chen, T Feng, J Feng, Zhaomin Huang, Y Lei, M Lei, Mingyu Sciences, Life Tang, G Tang, Guangpeng Yang, L Zhao, X Zhu, Wenfei Zhuang, Li Zhuang, W Zou, X
Source	Medline; PMC
abstract	Many viruses can cause respiratory diseases in humans. Although great advances have been achieved in methods of diagnosis, it remains challenging to identify pathogens in unexplained pneumonia (UP) cases. In this study, we applied next-generation sequencing (NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province, China. A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS. An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples. Human rhinovirus C was the virus most frequently detected and was identified in seven samples. Human measles virus, adenovirus B 55 and coxsackievirus A10 were also identified. Metagenomic sequencing also provided virus genomic sequences, which enabled genotype characterization and phylogenetic analysis. For cases of multiple infection, metagenomic sequencing afforded information regarding the quantity of each virus in the sample, which could be used to evaluate each viruses’ role in the disease. Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases.
has issue date	2016-12-02(xsd:dateTime)
bibo:doi	10.1007/s11427-016-0244-8
bibo:pmid	27921234
has license	cc-by
sha1sum (hex)	bcbababfe74df9aa2d3279651b2ac518137034f0
schema:url	https://doi.org/10.1007/s11427-016-0244-8
resource representing a document's title	Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique
has PubMed Central identifier	PMC7088591
has PubMed identifier	27921234
schema:publication	Sci China Life Sci
resource representing a document's body	covid:bcbababfe74df9aa2d3279651b2ac518137034f0#body_text
is schema:about of	named entity 'oropharyngeal' named entity 'virus' named entity 'Citation' named entity 'viruses' named entity 'NGS' named entity 'remains' named entity 'disease' named entity 'virus' named entity 'PNEUMONIA' named entity 'PATIENTS' named entity 'VIRUS' named entity 'ENABLED' named entity 'HOSPITALIZED' named entity 'OROPHARYNGEAL' named entity 'UNEXPLAINED' named entity 'PNEUMONIA' named entity 'SEVEN' named entity 'USED' named entity 'SAMPLES' named entity 'OF EACH' named entity 'APPLIED' named entity 'EVALUATE' named entity 'METAGENOMIC SEQUENCING' named entity 'STUDY' named entity 'PATHOGENS' named entity 'SEQUENCING' named entity 'SWABS' named entity 'PHYLOGENETIC ANALYSIS' named entity 'POTENTIAL' named entity 'INFORMATION' named entity 'SEQUENCES' named entity 'METAGENOMIC APPROACH' named entity 'DISEASE' named entity 'MULTIPLE INFECTION' named entity 'VIRUS IDENTIFICATION' named entity 'SPECIES' named entity 'METAGENOMICS' named entity 'HAVE' named entity 'CAUSE' named entity 'OUR' named entity 'DIAGNOSIS' named entity 'DETECTED' named entity 'UNEXPLAINED' named entity 'SIMULTANEOUS' named entity 'CHARACTERIZATION' named entity 'CHARACTERIZATION' named entity 'FREQUENTLY' named entity 'USING' named entity 'IDENTIFIED' named entity 'RESPIRATORY DISEASES' named entity 'CHINA' named entity 'PROVIDED' named entity 'TOTAL' named entity 'GUIZHOU PROVINCE'

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