About: Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate

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About: Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate
Creator	Zeng, Yi Wang, Xiaoli Hu, Qin Yan, Hong Li, Boye Wang, Jiao Yang, Yishu Zhang, Wenmei Zhang, Xiaoguang Id, Ying Id, † Zhu,
source	Medline; PMC
abstract	Here, we report the anti-human immunodeficiency virus (HIV) potency and underlying mechanisms of a Keggin polyoxometalate (PT-1, K(6)HPTi(2)W(10)O(40)). Our findings showed that PT-1 exhibited highly potent effects against a diverse group of HIV type 1 (HIV-1) strains and displayed low cytotoxicity and genotoxicity. The time-addition assay revealed that PT-1 acted at an early stage of infection, and these findings were supported by the observation that PT-1 had more potency against Env-pseudotyped virus than vesicular stomatitis virus glycoprotein (VSVG) pseudotyped virus. Surface plasmon resonance binding assays and flow cytometry analysis showed that PT-1 blocked the gp120 binding site in the CD4 receptor. Moreover, PT-1 bound directly to gp41 NHR (N36 peptide), thereby interrupting the core bundle formation of gp41. In conclusion, our data suggested that PT-1 may be developed as a new anti-HIV-1 agent through its effects on entry inhibition.
has issue date	2018-05-16(xsd:dateTime)
bibo:doi	10.3390/v10050265
bibo:pmid	29772712
has license	cc-by
sha1sum (hex)	bd067c850dd16252d8c195caeb129a3e304e5700
schema:url	https://doi.org/10.3390/v10050265
resource representing a document's title	Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate
has PubMed Central identifier	PMC5977258
has PubMed identifier	29772712
schema:publication	Viruses
resource representing a document's body	covid:bd067c850dd16252d8c195caeb129a3e304e5700#body_text
is schema:about of	named entity 'mechanisms' named entity 'potent' named entity 'strains' named entity 'core' named entity 'PT-1' named entity 'Inhibition' named entity 'HUMAN IMMUNODEFICIENCY VIRUS TYPE 1' named entity 'OUR' covid:arg/bd067c850dd16252d8c195caeb129a3e304e5700 named entity 'INHIBITION' named entity 'FINDINGS' named entity 'BOUND' named entity 'REVEALED' named entity 'ENTRY' named entity 'INTERRUPTING' named entity 'CORE' named entity 'INFECTION' named entity 'PEPTIDE' named entity 'OBSERVATION' named entity 'MECHANISMS' named entity 'MAY BE' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'DIVERSE' named entity 'CD4 RECEPTOR' named entity 'ENTRY' named entity 'HIGHLY' named entity 'CYTOTOXICITY' named entity 'POTENCY' named entity 'SURFACE PLASMON RESONANCE' named entity 'GLYCOPROTEIN' named entity 'GP41' named entity 'DISPLAYED' named entity 'EFFECTS' named entity 'HIV' named entity 'FLOW CYTOMETRY' named entity 'TIME' named entity 'INHIBITION' named entity 'BLOCKED' named entity 'LOW' named entity 'HERE' named entity 'ASSAY' named entity 'ANALYSIS' named entity 'ANTI-HIV-1 AGENT' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'SUPPORTED' named entity 'ENV' named entity 'BINDING SITE' named entity 'ITS' named entity 'BUNDLE' named entity 'ADDITION' named entity 'THESE' named entity 'EARLY STAGE' named entity 'CONCLUSION' named entity 'DATA' named entity 'BINDING ASSAYS' named entity 'REPORT' named entity 'STRAINS' named entity 'NEW' named entity 'DIRECTLY' named entity 'VIRUS' named entity 'GP120' named entity 'TYPE 1' named entity 'GENOTOXICITY' named entity 'GROUP' named entity 'UNDERLYING' named entity 'FORMATION' named entity 'gp41' named entity 'inhibition' named entity 'bundle' named entity 'HIV'

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