About: Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients

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About: Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients
Creator	López-Lastra, Marcelo Pino, Karla Angulo, Jenniffer Astudillo, Patricio Ferrés, Marcela Perez, Sebastián Biso De Carvalho, Joseane De Vasconcelos, Ribeiro Loss De Morais, Guilherme Tereza, Ana
Source	Medline; PMC
abstract	BACKGROUND: Single-nucleotide polymorphisms (SNPs) that impact on the differential expression of interleukin 28B (IL28B) are implicated in the progression of viral-induced diseases. In this prospective longitudinal cohort study, we evaluated the association between IL28B SNPs rs12979860 and rs8099917 and the clinical outcome of bronchiolitis in pediatric patients. METHODS: A total of 682 infants suffering from bronchiolitis, categorized based on the final clinical outcome as mild or severe, were genotyped for IL28B SNPs rs12979860 and rs8099917. RESULTS: When infants were categorized exclusively based on the final clinical outcome, no association was established between IL28B SNPs and the severity of bronchiolitis. However, when stratified by sex, the homozygotes for the minor alleles of rs12979860 (T) and rs8099917 (G) were associated with a mild disease in girls but not in boys. CONCLUSION: SNPs rs12979860 and rs8099917 correlate with the severity of bronchiolitis and display a sex bias, where GG rs8099917 and TT rs12979860 genotypes are associated with a mild disease in girls but not in boys. These findings suggest that innate immunity and female sex links with the outcome of the diseases induced by respiratory viruses, such as RSV.
has issue date	2019-10-23(xsd:dateTime)
bibo:doi	10.1038/s41390-019-0623-1
bibo:pmid	31645053
has license	no-cc
sha1sum (hex)	bd9f4f72cbcda0758701826d426c0c278e2a8af6
schema:url	https://doi.org/10.1038/s41390-019-0623-1
resource representing a document's title	Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients
has PubMed Central identifier	PMC7086532
has PubMed identifier	31645053
schema:publication	Pediatr Res
resource representing a document's body	covid:bd9f4f72cbcda0758701826d426c0c278e2a8af6#body_text
is schema:about of	named entity 'RESULTS' named entity 'boys' named entity 'RSV' named entity 'prospective' named entity 'Single-nucleotide polymorphisms' named entity 'progression' named entity 'genotype' named entity 'DISPLAY' named entity 'SNPS' named entity 'BASED' named entity 'RS12979860' named entity 'ASSOCIATION' named entity 'FINDINGS' named entity 'LINKS' named entity 'RSV' named entity 'FEMALE SEX' named entity 'BOYS' named entity 'STRATIFIED' named entity 'HOMOZYGOTES' named entity 'BACKGROUND' covid:arg/bd9f4f72cbcda0758701826d426c0c278e2a8af6 named entity 'CLINICAL' named entity 'WHERE' named entity 'PATIENTS' named entity 'DISEASES' named entity 'PEDIATRIC' named entity 'PROGRESSION' named entity 'PATIENTS' named entity 'IL28B' named entity 'PEDIATRIC' named entity 'BRONCHIOLITIS' named entity 'GENOTYPE' named entity 'CORRELATION' named entity 'SEVERITY' named entity 'RESULTS' named entity 'INDUCED' named entity 'ESTABLISHED' named entity 'THESE' named entity 'ALLELES' named entity 'MILD' named entity 'RESPIRATORY VIRUSES' named entity 'INNATE IMMUNITY' named entity 'IMPACT' named entity '28G' named entity 'INTERLEUKIN 28B' named entity 'METHODS' named entity 'MINOR' named entity 'SUGGEST' named entity 'IL28B' named entity 'FEMALE SEX' named entity 'PROSPECTIVE' named entity 'FINAL' named entity 'SEX' named entity 'SEX BIAS' named entity 'GIRLS' named entity 'OUTCOME' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISMS' named entity 'CONCLUSION' named entity 'TOTAL' named entity 'MILD DISEASE' named entity 'EVALUATED' named entity '682' named entity 'CLINICAL' named entity 'SEVERE' named entity 'VIRAL-' named entity 'DIFFERENTIAL EXPRESSION' named entity 'ASSOCIATED WITH' named entity 'INFANTS' named entity 'BRONCHIOLITIS' named entity 'BUT' named entity 'SEVERITY' named entity 'GENOTYPES'

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