About: SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)

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About: SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)
Creator	Letko, Michael Munster, Vincent Baric, Ralph Bushmaker, Trenton Saturday, Greg Schäfer, Alexandra Fischer, Robert Menachery, Vineet Hanley, Patrick Van Doremalen, Neeltje Figueroa, Dania
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats.
has issue date	2018-12-19(xsd:dateTime)
bibo:doi	10.3390/v10120727
bibo:pmid	30572566
has license	cc-by
sha1sum (hex)	be5bddac1b08e3f6c757bdbd6564255e6ee96f4a
schema:url	https://doi.org/10.3390/v10120727
resource representing a document's title	SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)
has PubMed Central identifier	PMC6316779
has PubMed identifier	30572566
schema:publication	Viruses
resource representing a document's body	covid:be5bddac1b08e3f6c757bdbd6564255e6ee96f4a#body_text
is schema:about of	named entity 'Rousettus' named entity 'coronavirus' named entity 'bats' named entity 'CORONAVIRUS' named entity 'NO CLINICAL SIGNS' named entity 'EXPERIMENT' named entity 'ROBUST' covid:arg/be5bddac1b08e3f6c757bdbd6564255e6ee96f4a named entity 'MODEST' named entity 'VIRAL RNA' named entity 'CHALLENGE' named entity 'INVESTIGATE' named entity 'DAY 3' named entity 'CAUSE' named entity 'USE' named entity 'POST' named entity 'INOCULATION' named entity 'INFECTION' named entity 'HUMAN' named entity 'EGYPTIAN' named entity 'SARS-LIKE CORONAVIRUS' named entity 'DOES NOT' named entity 'REPLICATE' named entity 'OROPHARYNGEAL' named entity 'SPECIFIC' named entity 'RESPIRATORY' named entity 'ANTIBODIES' named entity 'POSITIVE FOR' named entity 'INCREASE' named entity 'STUDY' named entity 'LIKE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'FOUND' named entity 'CONCLUSION' named entity 'OBSERVED' named entity 'ISOLATED' named entity 'RHINOLOPHUS SINICUS' named entity 'CURRENT' named entity 'BATS' named entity 'ABILITY' named entity 'RECEPTOR' named entity 'ANGIOTENSIN CONVERTING ENZYME 2' named entity 'TISSUES' named entity 'FRUIT BATS' named entity 'ROUSETTUS AEGYPTIACUS' named entity 'SWABS' named entity 'TO INFECT' named entity 'Rousettus' named entity 'positive' named entity 'bats' named entity 'antibodies' named entity 'clinical signs' named entity 'bats' named entity 'Does' named entity 'receptor' named entity 'angiotensin converting enzyme 2' named entity 'coronavirus' named entity 'Coronavirus' named entity 'robust' named entity 'necropsy' named entity 'urogenital' named entity 'viral RNA' named entity 'white blood cells' named entity 'transfection' named entity 'glycoprotein' named entity 'BHK' named entity 'sera' named entity 'Virus' named entity 'viral RNA' named entity 'Burlingame, CA' named entity 'BHK'

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