About: Immunoprophylaxis in fish by injection of mouse antibody genes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunoprophylaxis in fish by injection of mouse antibody genes
Creator	Cunningham, Charles Ahrens, Peter Cupit, Pauline Einer-Jensen, Katja Lorenzen, Ellen Lorenzen, Niels Secombes, Christopher
Source	Medline; PMC
abstract	Antibodies are a crucial part of the body's specific defense against infectious diseases and have considerable potential as therapeutic and prophylactic agents in humans and animals. The development of recombinant single-chain antibodies allows a genetic application strategy for prevention of infectious diseases. To test this in a fish model, a gene construct encoding a neutralizing single-chain antibody to the fish-pathogenic rhabdovirus VHSV (viral hemorrhagic septicemia virus) was administered to rainbow trout by intramuscular injection of plasmid DNA. Circulating recombinant antibodies could later be detected in the fish, and protective immunity to the viral disease was established.
has issue date	2000-01-01(xsd:dateTime)
bibo:doi	10.1038/81169
bibo:pmid	11062437
has license	no-cc
sha1sum (hex)	be75ec94c8c6b29fcda40df97b6fc6e730b78b6a
schema:url	https://doi.org/10.1038/81169
resource representing a document's title	Immunoprophylaxis in fish by injection of mouse antibody genes
has PubMed Central identifier	PMC7097139
has PubMed identifier	11062437
schema:publication	Nat Biotechnol
resource representing a document's body	covid:be75ec94c8c6b29fcda40df97b6fc6e730b78b6a#body_text
is schema:about of	named entity 'antibody' named entity 'neutralizing' named entity 'encoding' named entity 'INTRAMUSCULAR INJECTION' named entity 'ENCODING' named entity 'CONSIDERABLE' named entity 'PROPHYLACTIC' named entity 'DETECTED' named entity 'ANTIBODIES' named entity 'PATHOGENIC' named entity 'GENETIC' named entity 'BODY' named entity 'RHABDOVIRUS' named entity 'HUMANS' covid:arg/be75ec94c8c6b29fcda40df97b6fc6e730b78b6a named entity 'THERAPEUTIC' named entity 'SINGLE-CHAIN ANTIBODIES' named entity 'A GENE' named entity 'SPECIFIC' named entity 'LATER' named entity 'ANIMALS' named entity 'CIRCULATING' named entity 'PREVENTION OF' named entity 'VIRAL DISEASE' named entity 'ALLOWS' named entity 'STRATEGY' named entity 'PLASMID DNA' named entity 'INFECTIOUS DISEASES' named entity 'APPLICATION' named entity 'MODEL' named entity 'FISH' named entity 'ESTABLISHED' named entity 'HAVE' named entity 'DEVELOPMENT' named entity 'ADMINISTERED' named entity 'RAINBOW TROUT ' named entity 'PART OF' named entity 'RECOMBINANT ANTIBODIES' named entity 'POTENTIAL' named entity 'CONSTRUCT' named entity 'SINGLE-CHAIN ANTIBODY' named entity 'RECOMBINANT' named entity 'VHSV' named entity 'PROTECTIVE IMMUNITY' named entity '27S' named entity 'TO TEST' named entity 'DEFENSE' named entity 'humans' named entity 'prevention' named entity 'gene' named entity 'animals' named entity 'Antibodies' named entity 'intramuscular injection' named entity 'viral hemorrhagic septicemia virus' named entity 'antibody' named entity 'plasmid DNA' named entity 'recombinant antibodies' named entity 'gene construct' named entity 'hybridoma' named entity 'tence' named entity 'Invitrogen' named entity 'plasma' named entity 'ciliate' named entity 'single-chain antibodies' named entity 'parasitic' named entity 'transforming growth factor β' named entity 'cell cultures' named entity 'Recombinant' named entity 'antibody' named entity 'plasmid-borne' named entity 'gene' named entity 'epifluorescence microscope' named entity 'Plasmid' named entity 'neutralization test' named entity 'tetramethylrhodamine'

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