About: CCL28 chemokine: An anchoring point bridging innate and adaptive immunity

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About: CCL28 chemokine: An anchoring point bridging innate and adaptive immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CCL28 chemokine: An anchoring point bridging innate and adaptive immunity
Creator	Deng, Lei Mohan, Teena Wang, Bao-Zhong
Source	Elsevier; Medline; PMC
abstract	Chemokines are an extensive family of small proteins which, in conjunction with their receptors, guide the chemotactic activity of various immune cells throughout the body. CCL28, β- or CC chemokine, is involved in the host immunity at various epithelial and mucosal linings. The unique roles of CCL28 in several facets of immune responses have attracted considerable attention and may represent a promising approach to combat various infections. CCL28 displays a broad spectrum of antimicrobial activity against gram-negative and gram-positive bacteria, as well as fungi. Here, we will summarize various research findings regarding the antimicrobial activity of CCL28 and the relevant mechanisms behind it. We will explore how the structure of CCL28 is involved with this activity and how this function may have evolved. CCL28 displays strong homing capabilities for B and T cells at several mucosal and epithelial sites, and orchestrates the trafficking and functioning of lymphocytes. The chemotactic and immunomodulatory features of CCL28 through the interactions with its chemokine receptors, CCR10 and CCR3, will also be discussed in detail. Thus, in this review, we emphasize the dual properties of CCL28 and suggest its role as an anchoring point bridging the innate and adaptive immunity.
has issue date	2017-10-01(xsd:dateTime)
bibo:doi	10.1016/j.intimp.2017.08.012
bibo:pmid	28843907
has license	green-oa
sha1sum (hex)	bed493869199469ee87e5f50d139fef45f3fcf73
schema:url	https://doi.org/10.1016/j.intimp.2017.08.012
resource representing a document's title	CCL28 chemokine: An anchoring point bridging innate and adaptive immunity
has PubMed Central identifier	PMC5755716
has PubMed identifier	28843907
schema:publication	International Immunopharmacology
resource representing a document's body	covid:bed493869199469ee87e5f50d139fef45f3fcf73#body_text
is schema:about of	named entity 'T cells' named entity 'dual' named entity 'homing' named entity 'trafficking' named entity 'immunomodulatory' named entity 'anchoring' named entity 'POINT' named entity 'REVIEW' named entity 'PROPERTIES' named entity 'CCR3' named entity 'DUAL' named entity 'FUNCTIONING' named entity 'LININGS' named entity 'THEIR' named entity 'EPITHELIAL' named entity 'ANTIMICROBIAL ACTIVITY' named entity 'FAMILY' named entity 'FUNCTION' named entity 'STRUCTURE' named entity 'BRIDGING' named entity 'FEATURES' named entity 'CHEMOKINES' named entity 'IMMUNE RESPONSES' named entity 'SITES' named entity 'RELEVANT' named entity 'DISPLAYS' named entity 'ATTENTION' named entity 'GRAM-POSITIVE BACTERIA' named entity 'INFECTIONS' named entity 'SUGGEST' named entity 'HOMING' named entity 'NEGATIVE' named entity 'LYMPHOCYTES' named entity 'GUIDE' named entity 'IMMUNE CELLS' named entity 'MAY HAVE' named entity 'RECEPTORS' named entity 'CONSIDERABLE' named entity 'TRAFFICKING' named entity 'FUNGI' named entity 'REPRESENT' named entity 'VARIOUS' named entity 'APPROACH' named entity 'UNIQUE' named entity 'CCR10' named entity 'GRAM-' named entity 'ANCHORING' named entity 'CONJUNCTION' named entity 'EXTENSIVE' named entity 'CHEMOKINE' named entity 'BRIDGING' named entity 'CCL28' named entity 'ANCHORING' named entity 'ADAPTIVE IMMUNITY' named entity 'MUCOSAL' named entity 'SMALL' named entity 'T CELLS' named entity 'RESEARCH' named entity 'BODY' named entity 'EVOLVED' named entity 'CCL28' named entity 'CC CHEMOKINE' named entity 'INTERACTIONS' named entity 'HOST IMMUNITY' named entity 'HERE' named entity 'COMBAT' named entity 'IMMUNOMODULATORY' named entity 'INVOLVED' named entity 'FINDINGS' named entity 'CHEMOKINE RECEPTORS' named entity 'BROAD SPECTRUM' named entity 'ROLE' named entity 'HOW' named entity 'MECHANISMS' named entity 'ITS' named entity 'HAVE' named entity 'ADAPTIVE IMMUNITY' named entity 'STRONG' named entity 'PROTEINS'

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