About: Identification of highly conserved regions in L-segment of Crimean–Congo hemorrhagic fever virus and immunoinformatic prediction about potential novel vaccine

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About: Identification of highly conserved regions in L-segment of Crimean–Congo hemorrhagic fever virus and immunoinformatic prediction about potential novel vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of highly conserved regions in L-segment of Crimean–Congo hemorrhagic fever virus and immunoinformatic prediction about potential novel vaccine
Creator	Pervin, Tahmina Rahman Oany, Arafat Ishtiyaq Ahmad, Adil Uzzal Hossain, Mohammad
source	Medline; PMC
abstract	Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic viral disease with a disease fatality rate between 15% and 70%. Despite the wide range of distribution, the virus (CCHFV) is basically endemic in Africa, Asia, eastern Europe, and the Middle East. Acute febrile illness associated with petechiae, disseminated intravascular coagulation, and multiple-organ failure are the main symptoms of the disease. With all these fatal effects, CCHFV is considered a huge threat as no successful therapeutic approach is currently available for the treatment of this disease. In the present study, we have used the immunoinformatics approach to design a potential epitope-based vaccine against the RNA-dependent RNA polymerase-L of CCHFV. Both the T-cell and B-cell epitopes were assessed, and the epitope “DCSSTPPDR” was found to be the most potential one, with 100% conservancy among all the strains of CCHFV. The epitope was also found to interact with both type I and II major histocompatibility complex molecules and is considered nonallergenic as well. In vivo study of our proposed peptide is advised for novel universal vaccine production, which might be an effective path to prevent CCHF disease.
has issue date	2015-01-08(xsd:dateTime)
bibo:doi	10.2147/aabc.s75250
bibo:pmid	25609983
has license	cc-by-nc
sha1sum (hex)	bf87996bb6c0dbed5de9512ac2bab800417a8956
schema:url	https://doi.org/10.2147/aabc.s75250
resource representing a document's title	Identification of highly conserved regions in L-segment of Crimean–Congo hemorrhagic fever virus and immunoinformatic prediction about potential novel vaccine
has PubMed Central identifier	PMC4293217
has PubMed identifier	25609983
schema:publication	Adv Appl Bioinform Chem
resource representing a document's body	covid:bf87996bb6c0dbed5de9512ac2bab800417a8956#body_text
is schema:about of	named entity 'APPROACH' named entity 'RANGE' named entity 'ASIA' named entity 'TREATMENT' named entity 'ENDEMIC' named entity 'ORGAN FAILURE' named entity 'CONSIDERED' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'TO INTERACT WITH' named entity 'PATH' named entity 'VIRUS' named entity 'PETECHIAE' named entity 'MOLECULES' named entity 'DISEASE' named entity 'FATAL' named entity 'EPITOPE' named entity 'ASSOCIATED WITH' named entity 'VACCINE PRODUCTION' named entity 'THERAPEUTIC' named entity 'AVAILABLE' named entity 'POTENTIAL' named entity 'wide range' named entity 'strains' named entity 'virus' named entity 'SEGMENT' named entity '100%' named entity 'SYMPTOMS' named entity 'WIDE' named entity 'TO PREVENT' named entity 'T-CELL' named entity 'EFFECTIVE' named entity 'MAIN' named entity 'CHEMISTRY' named entity 'PREDICTION' named entity 'STRAINS' named entity 'B-CELL' named entity 'TICK' named entity 'DESIGN' named entity 'ACUTE FEBRILE ILLNESS' named entity 'THREAT' named entity 'OUR' named entity 'ZOONOTIC' named entity 'AFRICA' named entity 'DISSEMINATED INTRAVASCULAR COAGULATION' named entity 'IDENTIFICATION' named entity 'POTENTIAL' named entity 'NOVEL' named entity 'APPLICATIONS' named entity 'CONSERVED' named entity 'REGIONS' named entity 'VACCINE' named entity 'IS A' named entity 'BORNE' named entity 'PRESENT' named entity 'UNIVERSAL' named entity 'RATE' named entity 'ASSESSED' named entity 'HUGE' named entity 'USED' named entity 'CCHFV' named entity 'NOVEL' named entity 'HAVE' named entity 'EASTERN EUROPE' named entity 'BIOINFORMATICS' named entity 'SUCCESSFUL' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'IMMUNOINFORMATICS' named entity 'BASED' named entity 'VACCINE' named entity 'STUDY' named entity 'DISTRIBUTION' named entity '70%' named entity 'CRIMEAN-CONGO HEMORRHAGIC FEVER' named entity 'HIGHLY' named entity 'ABOUT' named entity 'CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS' named entity 'MIDDLE EAST' named entity 'CURRENTLY'

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