About: ERK signaling is triggered by hepatitis C virus E2 protein through DC-SIGN

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About: ERK signaling is triggered by hepatitis C virus E2 protein through DC-SIGN Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ERK signaling is triggered by hepatitis C virus E2 protein through DC-SIGN
Creator	Wang, Wen Ren, Hao Qi, Zhong-Tian Zhao, Lan-Juan
Source	Medline; PMC
abstract	Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a binding receptor for hepatitis C virus (HCV). Binding of HCV envelope protein E2 to target cells is a prerequisite to DC-SIGN-mediated signaling. Using cell lines with stable or transient expression of DC-SIGN, we investigated effects of soluble HCV E2 protein on ERK pathway. MEK and ERK are activated by the E2 in NIH3T3 cells stably expressing DC-SIGN. Treatment of the cells with antibody to DC-SIGN results in inhibition of the E2 binding as well as the E2-induced MEK and ERK activation. In HEK293T cells transiently expressing DC-SIGN, activation of MEK and ERK is also induced by the E2. Activation of ERK pathway by HCV E2 through DC-SIGN provides useful information for understanding cellular receptor-mediated signaling.
has issue date	2013-02-03(xsd:dateTime)
bibo:doi	10.1007/s12192-013-0405-3
bibo:pmid	23378214
has license	green-oa
sha1sum (hex)	c07827807bfebc70aaf5658ab0319c6df1f06fe1
schema:url	https://doi.org/10.1007/s12192-013-0405-3
resource representing a document's title	ERK signaling is triggered by hepatitis C virus E2 protein through DC-SIGN
has PubMed Central identifier	PMC3682013
has PubMed identifier	23378214
schema:publication	Cell Stress and Chaperones
resource representing a document's body	covid:c07827807bfebc70aaf5658ab0319c6df1f06fe1#body_text
is schema:about of	named entity 'activation' named entity 'cells' named entity 'ERK' named entity 'HEPATITIS C VIRUS' named entity 'ANTIBODY' named entity 'ERK' named entity 'INVESTIGATED' named entity 'NIH3T3' named entity 'TREATMENT' named entity 'MEDIATED' named entity 'SIGNALING' named entity 'IS A' named entity 'ENVELOPE PROTEIN' named entity 'HCV' named entity 'MEK' named entity 'UNDERSTANDING' named entity 'ACTIVATION' named entity 'SIGN' named entity 'DC-SIGN' named entity 'CELLS' named entity 'PROVIDES' named entity 'CELLULAR' named entity 'PROTEIN ' named entity 'BINDING' named entity 'INTERCELLULAR ADHESION MOLECULE-3' named entity 'INDUCED' named entity 'CELL LINES' named entity 'ERK' named entity 'DC-SIGN' named entity 'E2 PROTEIN' named entity 'HEPATITIS C VIRUS E2' named entity 'TRANSIENT EXPRESSION' named entity 'ERK ACTIVATION' named entity 'SIGNALING' named entity 'RECEPTOR' named entity 'USEFUL INFORMATION' named entity 'SOLUBLE' named entity 'HEK293T' named entity 'TARGET CELLS' named entity 'PREREQUISITE' named entity 'INHIBITION' named entity 'PATHWAY' named entity 'STABLE' named entity 'RESULTS' named entity 'E2 PROTEIN' named entity 'EFFECTS' named entity 'USING' named entity 'DENDRITIC CELL' named entity 'SPECIFIC' named entity 'PROTEIN ' named entity 'ACTIVATED' named entity 'TRIGGERED BY' named entity 'HEK293T' named entity 'activated' named entity 'effects' named entity 'DC-SIGN' named entity 'hepatitis C virus' named entity 'ERK' named entity 'ERK pathway' named entity 'DC-SIGN' named entity 'DC-SIGN' named entity 'ERK pathway' named entity 'hepatitis C virus' named entity 'HCV' named entity 'NIH3T3' named entity 'Dendritic cell' named entity 'intercellular adhesion molecule' named entity 'ERK' named entity 'HEK293T' named entity 'DC-SIGN' named entity 'HCV' named entity 'protein' named entity 'HCV' named entity 'HCV' named entity 'kinases' named entity 'PBS' named entity 'neurotoxicity' named entity 'HCV'

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