About: An unusual cause of fever of unknown origin with enlarged lymph nodes

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About: An unusual cause of fever of unknown origin with enlarged lymph nodes—relapsing polychondritis: A case report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An unusual cause of fever of unknown origin with enlarged lymph nodes—relapsing polychondritis: A case report
Creator	Liu, Wei Mao, Bing Jiang, Hongli Jing, Han
Source	Medline; PMC
abstract	INTRODUCTION: Fever of unknown origin (FUO) is a common initial presentation leading to a diagnostic challenge. PATIENT CONCERNS: A 3-month history of moderate-to-high fever was reported in an otherwise healthy 54-year-old man. Enhanced computed tomography (CT) scans of his chest showed a remarkable progressive enlargement of bilateral cervical, supraclavicular, hilar, and mediastinal lymph nodes within 2 weeks. Bronchofibroscopy manifested obvious luminal stenosis with swelling, thick pale mucosa, and disappearing of structures of trachea cricoid cartilage, followed by a 18F-fluorodeoxyglucose positron-emission tomography–computed tomography (18F-FDG PET/CT) with intense symmetric FDG uptake in larynx, tracheobronchial tree, and hilar, mediastinal, and axillary lymph nodes being demonstrated. DIAGNOSIS: A diagnosis of relapsing polychondritis (RP) was finally reached. INTERVENTIONS: The patient received methylprednisolone 40 mg daily with a gradual tapering in a 4-month follow-up. OUTCOMES: The patient experienced no relapse of fever and lymph nodes enlargement in the 4-month follow-up. LESSONS: Even though long-term fever with multiple lymphadenectasis usually lead to a diagnosis of lymphoma, the bronchoscopic features and evidence from 18F-FDG PET/CT in this case were much more approximate to RP, indicating an importance of a sensible differential diagnosis of RP in patients who present with nonspecific features such as FUO and lymph nodes enlargement. Keeping a high index of clinical suspicion in these patients can help recognize uncommon of RP and promote diagnosis and treatment. Our case highlights the significance of 18F-FDG PET/CT in helping reaching the diagnosis of RP in this condition. This report provides new data regarding the diagnostic difficulties of this rare type of autoimmune disease, and further investigations are needed as cases accumulate.
has issue date	2017-11-17(xsd:dateTime)
bibo:doi	10.1097/md.0000000000008734
bibo:pmid	29145318
has license	cc-by-nc-sa
sha1sum (hex)	c1909700d68a75f5d5390928295e7a4949c4cc41
schema:url	https://doi.org/10.1097/md.0000000000008734
resource representing a document's title	An unusual cause of fever of unknown origin with enlarged lymph nodes—relapsing polychondritis: A case report
has PubMed Central identifier	PMC5704863
has PubMed identifier	29145318
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:c1909700d68a75f5d5390928295e7a4949c4cc41#body_text
is schema:about of	named entity 'FEVER OF UNKNOWN ORIGIN' named entity 'IS A' named entity 'DIAGNOSTIC' named entity 'UNUSUAL' named entity 'RELAPSING POLYCHONDRITIS' named entity 'CASE REPORT' named entity 'ENLARGED LYMPH NODES' named entity 'CAUSE' named entity 'FEVER OF UNKNOWN ORIGIN' named entity 'INTRODUCTION' named entity 'A COMMON' named entity 'INITIAL PRESENTATION' named entity 'LEADING' named entity 'CHALLENGE' covid:arg/c1909700d68a75f5d5390928295e7a4949c4cc41 named entity 'Fever' named entity 'lymph' named entity 'relapsing polychondritis' named entity 'leading' named entity 'biopsy' named entity 'differential diagnosis' named entity 'enlarged lymph nodes' named entity 'mediastinal' named entity 'body temperature' named entity 'syphilis' named entity 'cough' named entity 'sudden death' named entity 'EBV' named entity 'assay' named entity 'toxoplasmosis' named entity 'autoimmune disorder' named entity 'tuberculosis' named entity 'dyspnea' named entity 'tracheobronchus' named entity 'immunosuppressive agent' named entity 'rheumatoid factor' named entity 'antibody' named entity 'tachypnoea' named entity 'auscultation' named entity 'Fever' named entity 'hepatitis viruses' named entity 'etiology' named entity 'neoplastic' named entity 'larynx' named entity 'Coxiella burnetii' named entity 'bronchoscopy' named entity 'ng/mL' named entity 'thrombocythemia' named entity 'methylprednisolone' named entity 'polyarthritis' named entity 'clinical practice' named entity 'Brucella' named entity 'respiratory tract' named entity 'FUO' named entity 'Rickettsia' named entity 'cartilaginous' named entity 'antibody' named entity 'FUO' named entity 'mediastinal' named entity 'fever' named entity 'hoarseness' named entity 'anemia' named entity 'lymphoma' named entity 'sore throat' named entity 'erythrocyte sedimentation rate' named entity 'lymph nodes' named entity 'inflammation' named entity 'tracheobronchial' named entity 'CTs' named entity 'cartilage' named entity 'anemia' named entity 'vomiting' named entity 'methylprednisolone' named entity 'fever' named entity 'prognosis' named entity 'endobronchial ultrasound' named entity 'FUO' named entity 'productive cough'

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