About: Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus

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About: Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus
Creator	Ikuta, Kazuyoshi Li, Gui-Mei Yamate, Masanobu Yamashita, Makiko
Source	Elsevier; Medline; PMC
abstract	Abstract Pathological characterization of autopsied tissues from patients with SARS revealed severe damage in restricted tissues, such as lung, with no apparent cell damage in other tissues, such as intestine and brain. Here, we examined the susceptibility of neural cell lines of human (OL) and rat (C6) origins to SARS-associated coronavirus. Both of the neural cell lines showed no apparent cytopathic effects (CPE) by infection but produced virus with infectivity of 102–5 per ml, in sharp contrast to the production by infected Vero E6 cells of >109 per ml that showed a lytic infection with characteristic rounding CPE. Interestingly, the infection of intestinal cell line CaCo-2 also induced no apparent CPE, with production of the virus at a slightly lower level as that of the Vero E6 cell culture. Notably, the cellular receptor for the virus, angiotensin-converting enzyme 2 was expressed at similar levels on Vero E6 and CaCo-2 cells, but at undetectable levels on OL and C6 cells.
has issue date	2005-08-19(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2005.06.061
bibo:pmid	15992768
has license	els-covid
sha1sum (hex)	c2eba84cd09b95e1ac81838474be54d908bb7b06
schema:url	https://doi.org/10.1016/j.bbrc.2005.06.061
resource representing a document's title	Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus
has PubMed Central identifier	PMC7092822
has PubMed identifier	15992768
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:c2eba84cd09b95e1ac81838474be54d908bb7b06#body_text
is schema:about of	named entity 'cells' named entity 'effects' named entity 'neural cell' named entity 'Vero' named entity 'cell culture' named entity 'apparent' named entity 'level' named entity 'virus' named entity 'LEVEL' named entity 'EXAMINED' named entity 'LYTIC INFECTION' named entity 'EXPRESSED' named entity 'VERO' named entity 'LEVELS' named entity 'HUMAN' named entity 'PER ML' named entity 'SLIGHTLY' named entity 'SIMILAR' named entity 'UNDETECTABLE' named entity 'VIRUS' named entity 'INTESTINAL CELL LINE' named entity 'CONTRAST' named entity 'HERE' named entity 'REVEALED' named entity 'SEVERE' named entity 'SUSCEPTIBILITY' named entity 'RAT' named entity 'VERO E6 CELL' named entity 'CELL DAMAGE' named entity 'LOWER' covid:arg/c2eba84cd09b95e1ac81838474be54d908bb7b06 named entity 'HUMAN' named entity 'CACO-2' named entity 'SHARP' named entity 'CYTOPATHIC EFFECTS' named entity 'INFECTED' named entity 'SARS-ASSOCIATED CORONAVIRUS' named entity 'APPARENT' named entity 'CHARACTERISTIC' named entity 'INDUCED' named entity 'PATHOLOGICAL' named entity 'INTESTINE' named entity 'BUT' named entity 'SARS' named entity 'NEURAL CELL' named entity 'LUNG' named entity 'ORIGINS' named entity 'CELL CULTURE' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'SARS' named entity 'INFECTION' named entity 'CELLULAR' named entity 'PRODUCTION' named entity 'NEURAL CELL' named entity 'CORONAVIRUS' named entity 'SUSCEPTIBILITY' named entity 'CELL LINES' named entity 'CPE' named entity 'AND BRAIN' named entity 'DAMAGE' named entity 'PATIENTS' named entity 'RECEPTOR' named entity 'INFECTIVITY' named entity 'CELL LINES' named entity 'RAT' named entity 'CACO-2 CELLS' named entity 'CHARACTERIZATION' named entity 'INFECTION' named entity 'TISSUES' named entity 'CELLS' named entity 'RESTRICTED' named entity 'patients' named entity 'neural cell' named entity 'levels' named entity 'CaCo-2' named entity 'human' named entity 'infection' named entity 'infection'

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