About: Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room

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About: Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room
Creator	Wang, Lin Liu, Jien-Wei Lee, Ing-Kit Huang, Wen-Chi Chang, Tzu-Yao Chen, Chien-Chih Huang, Shi-Yu Hung, Shih-Chiang
source	PMC
abstract	BACKGROUND: Clinical differentiation of influenza from dengue and other febrile illnesses (OFI) is difficult, and available rapid diagnostic tests have limited sensitivity. METHODS: We conducted a retrospective study to compare clinical and laboratory findings between (i) influenza and dengue and (ii) influenza and OFI. RESULTS: Of 849 enrolled patients, the mean time between illness onset and hospital presentation was 1.7, 3.7, and 3 days for influenza, dengue, and OFI, respectively. Among pediatric patients (≤18 years) (445 influenza, 24 dengue, and 130 OFI), we identified absence of rashes, no leukopenia, and no marked thrombocytopenia (platelet counts <100 × 10(9) cells/L) as predictors to distinguish influenza from dengue, whereas rhinorrhea, malaise, sore throat, and mild thrombocytopenia (platelet counts 100-149 × 10(9)/L) were predictors that differentiated influenza from OFI. Among adults (>18 years) (81 influenza, 124 dengue, and 45 OFI), no leukopenia and no marked thrombocytopenia distinguished influenza from dengue, while rhinorrhea and malaise differentiated influenza from OFI. A diagnostic algorithm developed to distinguish influenza from dengue using rash, leukopenia, and marked thrombocytopenia showed >90% sensitivity to identify influenza in pediatric patients. CONCLUSIONS: This study identified simple clinical and laboratory parameters that can assist clinicians to distinguish influenza from dengue and OFI. These findings may help clinicians diagnose influenza and facilitate appropriate management of affected patients, particularly in resource-poor settings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0623-z) contains supplementary material, which is available to authorized users.
has issue date	2014-11-25(xsd:dateTime)
bibo:doi	10.1186/s12879-014-0623-z
bibo:pmid	25421019
has license	cc-by
sha1sum (hex)	c316bbd2cf404d0a96daf6c1966f2041181c9431
schema:url	https://doi.org/10.1186/s12879-014-0623-z
resource representing a document's title	Use of simple clinical and laboratory predictors to differentiate influenza from dengue and other febrile illnesses in the emergency room
has PubMed Central identifier	PMC4245735
has PubMed identifier	25421019
schema:publication	BMC Infect Dis
resource representing a document's body	covid:c316bbd2cf404d0a96daf6c1966f2041181c9431#body_text
is schema:about of	named entity 'DENGUE' named entity 'MANAGEMENT' named entity 'influenza' named entity 'influenza' named entity 'influenza' named entity 'influenza' named entity 'platelet counts' named entity 'leukopenia' named entity 'OFI' named entity 'pediatric patients' named entity 'dengue' named entity 'dengue' named entity 'pediatric patients' named entity 'OFI' named entity 'OFI' named entity 'dengue' named entity 'dengue' named entity 'febrile' named entity 'H1N1' named entity 'malaise' named entity 'malaise' named entity 'rhinorrhea' named entity 'OFI' named entity 'dengue' named entity 'abdominal pain' named entity 'respiratory tract' named entity 'OFI' named entity 'influenza' named entity 'influenza' named entity 'dengue' named entity 'enzyme-linked immunosorbent assay' named entity 'predictive model' named entity 'dengue' named entity 'Pediatric' named entity '1.2' named entity 'influenza' named entity 'immunoglobulin' named entity '13.5' named entity 'dengue' named entity 'Taiwan' named entity 'influenza infection' named entity 'OFI' named entity 'rash' named entity 'Pneumonia' named entity 'influenza' named entity 'probability' named entity 'influenza' named entity 'influenza' named entity 'dengue' named entity 'malaise' named entity 'influenza' named entity 'sore throat' named entity 'Influenza-like illness' named entity 'thrombocytopenia' named entity 'testing laboratory' named entity 'dengue' named entity 'epithelial cells' named entity 'respiratory illnesses' named entity 'pharyngitis' named entity 'virus' named entity 'sore throat' named entity 'influenza' named entity 'febrile' named entity 'influenza' named entity 'dengue' named entity 'probability' named entity 'febrile illness' named entity 'gastrointestinal bleeding' named entity 'febrile' named entity 'medical center' named entity 'OFI' named entity 'viremia' named entity 'dengue' named entity 'influenza'

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