About: Reverse Genetics of Measles Virus and Resulting Multivalent Recombinant Vaccines: Applications of Recombinant Measles Viruses

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About: Reverse Genetics of Measles Virus and Resulting Multivalent Recombinant Vaccines: Applications of Recombinant Measles Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reverse Genetics of Measles Virus and Resulting Multivalent Recombinant Vaccines: Applications of Recombinant Measles Viruses
Creator	Griffin, D Oldstone, M Billeter, M Naim, H Udem, S
Source	Medline; PMC
abstract	An overview is given on the development of technologies to allow reverse genetics of RNA viruses, i.e., the rescue of viruses from cDNA, with emphasis on nonsegmented negative-strand RNA viruses ( Mononegavirales ), as exemplified for measles virus (MV). Primarily, these technologies allowed site-directed mutagenesis, enabling important insights into a variety of aspects of the biology of these viruses. Concomitantly, foreign coding sequences were inserted to (a) allow localization of virus replication in vivo through marker gene expression, (b) develop candidate multivalent vaccines against measles and other pathogens, and (c) create candidate oncolytic viruses. The vector use of these viruses was experimentally encouraged by the pronounced genetic stability of the recombinants unexpected for RNA viruses, and by the high load of insertable genetic material, in excess of 6 kb. The known assets, such as the small genome size of the vector in comparison to DNA viruses proposed as vectors, the extensive clinical experience of attenuated MV as vaccine with a proven record of high safety and efficacy, and the low production cost per vaccination dose are thus favorably complemented.
has issue date	2009-01-01(xsd:dateTime)
bibo:doi	10.1007/978-3-540-70523-9_7
bibo:pmid	19198565
has license	no-cc
sha1sum (hex)	c35ed931f6ea3b4dd3b6bce15c68f5915043bf96
schema:url	https://doi.org/10.1007/978-3-540-70523-9_7
resource representing a document's title	Reverse Genetics of Measles Virus and Resulting Multivalent Recombinant Vaccines: Applications of Recombinant Measles Viruses
has PubMed Central identifier	PMC7120638
has PubMed identifier	19198565
schema:publication	Measles
resource representing a document's body	covid:c35ed931f6ea3b4dd3b6bce15c68f5915043bf96#body_text
is schema:about of	named entity 'genetic' named entity 'gene' named entity 'recombinants' named entity 'RNA' named entity 'Virus' named entity 'Measles' named entity 'REVERSE GENETICS' named entity 'OVERVIEW' named entity 'LOAD' named entity 'DEVELOPMENT' named entity 'GENE EXPRESSION' named entity 'IMPORTANT' named entity 'STRAND' named entity 'FOREIGN' named entity 'RECOMBINANTS' named entity 'MEASLES' named entity '28A' named entity 'GIVEN' named entity 'REVERSE GENETICS' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'RNA VIRUSES' named entity 'MARKER GENE' named entity 'MONONEGAVIRALES' named entity 'INSIGHTS' named entity 'RESCUE' named entity 'CODING' named entity 'NEGATIVE' named entity 'VECTOR' named entity 'RESULTING' named entity 'TECHNOLOGIES' named entity 'ONCOLYTIC VIRUSES' named entity 'USE OF' named entity 'VIRUS REPLICATION IN VIVO' named entity 'PATHOGENS' named entity 'UNEXPECTED' named entity 'ALLOW' named entity 'GENETIC STABILITY' named entity 'ENABLING' named entity 'INSERTED' named entity 'VACCINES' named entity 'MEASLES VIRUS' named entity 'RECOMBINANT' named entity 'APPLICATIONS' named entity 'CREATE' named entity 'LOCALIZATION' named entity 'VIRUSES' named entity 'THESE' named entity 'MEASLES VIRUS' named entity 'CANDIDATE' named entity 'HIGH' named entity 'BIOLOGY' named entity 'SEQUENCES' named entity 'VARIETY' named entity 'CDNA' named entity 'VIRUSES' named entity 'RECOMBINANT VACCINES' named entity 'MEASLES' named entity 'viruses' named entity 'viruses' named entity 'site-directed mutagenesis' named entity 'recombinants' named entity 'vector' named entity 'vaccines' named entity 'marker gene' named entity 'Reverse Genetics' named entity 'Recombinant' named entity 'SIV' named entity 'gene' named entity 'genetic material' named entity 'del Valle' named entity 'del Valle' named entity 'Qbeta' named entity 'Escherichia coli' named entity 'protein production' named entity 'RSV' named entity 'reading frame' named entity 'Paramyxoviridae'

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