About: Novel coronavirus-like particles targeting cells lining the respiratory tract

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About: Novel coronavirus-like particles targeting cells lining the respiratory tract Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Novel coronavirus-like particles targeting cells lining the respiratory tract
Creator	Milewska, Aleksandra Pyrc, Krzysztof Zeglen, Slawomir Rajfur, Zenon Nowak, Paulina Szczepanski, Artur Ochman, Marek Dabrowska, Agnieszka Jasik, Krzysztof Naskalska, Antonina
source	Medline; PMC
abstract	Virus like particles (VLPs) produced by the expression of viral structural proteins can serve as versatile nanovectors or potential vaccine candidates. In this study we describe for the first time the generation of HCoV-NL63 VLPs using baculovirus system. Major structural proteins of HCoV-NL63 have been expressed in tagged or native form, and their assembly to form VLPs was evaluated. Additionally, a novel procedure for chromatography purification of HCoV-NL63 VLPs was developed. Interestingly, we show that these nanoparticles may deliver cargo and selectively transduce cells expressing the ACE2 protein such as ciliated cells of the respiratory tract. Production of a specific delivery vector is a major challenge for research concerning targeting molecules. The obtained results show that HCoV-NL63 VLPs may be efficiently produced, purified, modified and serve as a delivery platform. This study constitutes an important basis for further development of a promising viral vector displaying narrow tissue tropism.
has issue date	2018-09-05(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0203489
bibo:pmid	30183777
has license	cc-by
sha1sum (hex)	c49543f507a07bcef2a9568fa458fac552d51fcd
schema:url	https://doi.org/10.1371/journal.pone.0203489
resource representing a document's title	Novel coronavirus-like particles targeting cells lining the respiratory tract
has PubMed Central identifier	PMC6124810
has PubMed identifier	30183777
schema:publication	PLoS One
resource representing a document's body	covid:c49543f507a07bcef2a9568fa458fac552d51fcd#body_text
is schema:about of	named entity 'efficiently' named entity 'system' named entity 'Novel' named entity 'TARGETING' covid:arg/c49543f507a07bcef2a9568fa458fac552d51fcd named entity 'RESPIRATORY TRACT' named entity 'CELLS LINING' named entity 'VECTOR' named entity 'NATIVE FORM' named entity 'CHROMATOGRAPHY' named entity 'ASSEMBLY' named entity 'PARTICLES' named entity 'BASIS' named entity 'MAJOR' named entity 'VIRAL STRUCTURAL PROTEINS' named entity 'DEVELOPMENT' named entity 'VIRUS' named entity 'GENERATION' named entity 'STRUCTURAL PROTEINS' named entity 'PURIFICATION' named entity 'PROCEDURE' named entity 'PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'MOUSE HEPATITIS VIRUS' named entity 'SPECIFIC' named entity 'MAY BE' named entity 'TISSUE TROPISM' named entity 'DELIVERY' named entity 'PURIFIED' named entity 'POTENTIAL' named entity 'SYSTEM' named entity 'THESE' named entity 'ACE2' named entity 'VIRAL VECTOR' named entity 'USING' named entity 'MODIFIED' named entity 'NOVEL' named entity 'FOR RESEARCH' named entity 'OBTAINED' named entity 'RESPIRATORY TRACT' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'PROTEIN ' named entity 'CARGO' named entity 'CELLS' named entity 'NANOPARTICLES' named entity 'LIKE' named entity 'RESULTS' named entity 'PARTICLES' named entity 'NOVEL CORONAVIRUS' named entity 'EVALUATED' named entity 'VLPS' named entity 'VACCINE' named entity 'EXPRESSION' named entity 'LIKE' named entity 'DISPLAYING' named entity 'NARROW' named entity 'AVIAN INFECTIOUS BRONCHITIS VIRUS' named entity 'DELIVER' named entity 'CHALLENGE' named entity 'MOLECULES' named entity 'HCOV-NL63' named entity 'TO FORM' named entity 'DESCRIBE' named entity 'PLATFORM' named entity 'TARGETING' named entity 'SERVE' named entity 'A MAJOR' named entity 'IMPORTANT' named entity 'IS A' named entity 'PRODUCTION' named entity 'CILIATED CELLS' named entity 'STUDY' named entity 'TIME'

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