About: Development of a Luminex assay for the detection of swine antibodies to non-structural proteins of foot-and-mouth disease virus

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About: Development of a Luminex assay for the detection of swine antibodies to non-structural proteins of foot-and-mouth disease virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of a Luminex assay for the detection of swine antibodies to non-structural proteins of foot-and-mouth disease virus
Creator	Chen, Tsu-Han Lee, Fan Lee, Ming-Chang Lin, Yeou-Liang Pan, Chu-Hsiang Shih, Chia-Ni Tsai, Hsiang-Jung
Source	Elsevier; Medline; PMC
abstract	Abstract Foot-and mouth disease (FMD), swine vesicular disease (SVD), and vesicular stomatitis (VS) are highly contagious vesicular diseases of swine but are not easy to differentiate clinically. For the purpose of instant detecting of FMD and differentiating it from the other vesicular diseases, a Luminex assay was developed. Sera from 64 infected, 307 vaccinated, and 280 naïve pigs were tested by the Luminex assay. Diagnostic sensitivity of the assay was 100%. Diagnostic specificity of the assay was 98.7% in vaccinated pigs and 97.5% to 100% in naïve pigs. Agreement between the results from the Luminex assay and those from a 3ABC polypeptide blocking ELISA was 96.3% with kappa statistics of 0.92. The Luminex assay can detect the immune response to NSP-3ABC in swine as early as eight days post-infection. Moreover, all of the 15 vaccinated but unprotected pigs were all detected by the Luminex assay. The results indicated that the Luminex assay has potential with specificity in detecting antibodies to FMDV 3ABC NSP and in distinguishing FMDV-infected pigs from with either SVDV or VSV.
has issue date	2013-10-31(xsd:dateTime)
bibo:doi	10.1016/j.jim.2013.08.002
bibo:pmid	23962586
has license	els-covid
sha1sum (hex)	c661173284b3ef122ecdbc9a848b5d9aaa81e447
schema:url	https://doi.org/10.1016/j.jim.2013.08.002
resource representing a document's title	Development of a Luminex assay for the detection of swine antibodies to non-structural proteins of foot-and-mouth disease virus
has PubMed Central identifier	PMC7127766
has PubMed identifier	23962586
schema:publication	Journal of Immunological Methods
resource representing a document's body	covid:c661173284b3ef122ecdbc9a848b5d9aaa81e447#body_text
is schema:about of	named entity 'SWINE' named entity 'NON-STRUCTURAL PROTEINS' named entity 'LUMINEX ASSAY' named entity 'differentiate' named entity 'vesicular' named entity 'diseases' named entity 'potential' named entity 'proteins' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'DEVELOPMENT' named entity 'SPECIFICITY' named entity 'LUMINEX ASSAY' named entity 'VSV' named entity 'POST' named entity 'EITHER' named entity 'VACCINATED' named entity 'RESPONSE TO' named entity 'SERA' named entity 'DIFFERENTIATING' named entity 'ASSAY' covid:arg/c661173284b3ef122ecdbc9a848b5d9aaa81e447 named entity 'INFECTED' named entity 'DIFFERENTIATE' named entity 'ELISA' named entity 'FOOT' named entity 'INFECTION' named entity 'DIAGNOSTIC SENSITIVITY' named entity 'DAYS' named entity 'ANTIBODIES' named entity 'INSTANT' named entity 'SWINE VESICULAR DISEASE' named entity 'DIAGNOSTIC SPECIFICITY' named entity 'RESULTS' named entity 'DISEASES' named entity 'HIGHLY' named entity 'IMMUNE RESPONSE' named entity 'DETECTING' named entity 'EASY' named entity 'EARLY' named entity 'INDICATED' named entity 'KAPPA' named entity 'DISTINGUISHING' named entity 'NSP' named entity 'TESTED' named entity 'POLYPEPTIDE' named entity 'ANTIBODIES' named entity 'DETECTION' named entity '100%' named entity 'FMDV' named entity 'FMD' named entity 'PURPOSE' named entity 'BLOCKING' named entity 'AGREEMENT' named entity 'DETECT' named entity '0.92' named entity 'DETECTED' named entity 'SWINE' named entity 'STATISTICS' named entity 'POTENTIAL' named entity 'VESICULAR STOMATITIS ' named entity 'PIGS' named entity 'VESICULAR' named entity 'MOUTH DISEASE' named entity 'BUT' named entity 'infected' named entity 'assay' named entity 'assay' named entity 'polypeptide' named entity 'contagious' named entity 'VSV' named entity 'statistics' named entity 'sensitivity' named entity 'FMD' named entity 'vesicular' named entity 'VSV'

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