About: SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals

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About: SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
Creator	Ca, Orengo Hm, Scholes Jg, Lees Jm, Santini Nl, Dawson Sd, Lam Sjl, Edwards Vp, Waman
topic	covid:c66cfb004c7c3a1bbacb6e7c8bf306a100899885#this
source	BioRxiv
abstract	SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor binding contributes to the viral host range, S-protein:ACE2 complexes from other animals have not been investigated widely. To predict infection risks, we modelled S-protein:ACE2 complexes from 215 vertebrate species, calculated changes in the energy of the complex caused by mutations in each species, relative to human ACE2, and correlated these changes with COVID-19 infection data. We also analysed structural interactions to better understand the key residues contributing to affinity. We predict that mutations are more detrimental in ACE2 than TMPRSS2. Finally, we demonstrate phylogenetically that human SARS-CoV-2 strains have been isolated in animals. Our results suggest that SARS-CoV-2 can infect a broad range of mammals, but few fish, birds or reptiles. Susceptible animals could serve as reservoirs of the virus, necessitating careful ongoing animal management and surveillance.
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1101/2020.05.01.072371
has license	biorxiv
sha1sum (hex)	c66cfb004c7c3a1bbacb6e7c8bf306a100899885
schema:url	https://doi.org/10.1101/2020.05.01.072371
resource representing a document's title	SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
schema:publication	bioRxiv
resource representing a document's body	covid:c66cfb004c7c3a1bbacb6e7c8bf306a100899885#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/c66cfb004c7c3a1bbacb6e7c8bf306a100899885
is schema:about of	named entity 'human' named entity 'fish' named entity 'animal' named entity 'virus' named entity 'intermediate host' named entity 'ACE2' named entity 'BROAD' named entity 'ISOLATED' named entity 'TMPRSS2' named entity 'HOST CELLS' named entity 'INFECTIONS' named entity 'MUTATIONS' named entity 'FISH' named entity 'key' named entity 'ACE2' named entity 'infection' named entity 'SARS-CoV-2' named entity 'strains' named entity 'cells' named entity 'investigated' named entity 'complexes' named entity 'mammals' named entity 'vertebrate' named entity 'broad' named entity 'correlated' named entity 'animals' named entity 'host' named entity 'ACE2' named entity 'receptor' named entity 'SARS-CoV-2' named entity 'protein' named entity 'mammals' named entity 'protein' named entity 'SARS-CoV-2' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity 'infection' named entity 'protein' named entity 'human' named entity 'cow' named entity 'binding affinities' named entity 'gold standard' named entity 'cell entry' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'TMPRSS2' named entity 'host range' named entity 'SARS-CoV-2' named entity 'host cell' named entity 'TMPRSS2' named entity 'non-human animals' named entity 'ΔΔG' named entity 'binding energy' named entity 'ACE2' named entity 'NCBI' named entity 'betacoronaviruses' named entity 'infection' named entity 'protein' named entity 'vertebrate' named entity 'highly conserved' named entity 'anthroponotic' named entity 'ΔΔG' named entity 'SARS-CoV' named entity 'horseshoe bat' named entity 'infection' named entity 'community sequencing' named entity 'homology modelling' named entity 'GISAID' named entity 'SARS-CoV-2' named entity 'primate' named entity 'host range' named entity 'horseshoe bat' named entity 'ΔΔG' named entity 'TMPRSS2' named entity 'phylogenetic diversity'

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