About: Pathogenesis of rotavirus-induced diarrhea: Preliminary studies in miniature swine piglet

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pathogenesis of rotavirus-induced diarrhea: Preliminary studies in miniature swine piglet
Creator	Estes, Mary Graham, David Sackman, Jeffrey
source	PMC
abstract	The pathogenesis of diarrhea caused by rotavirus infection was studied in miniature swine piglets. The animals were inoculated orally with 2×10(7) plaque-forming units of porcine rotavirus (OSU strain). During the height of diarrhea, intestinal function was investigated byin vivo perfusion of a 30-cm segment of proximal jejunum and a 30-cm segment of distal ileum. Absorption of Na(+) and water decreased and 3-O-methylglucose transport was markedly reduced,P<0.01 compared to control animals. Mucosal lactase and sucrase levels were depressed in both the jejunum and ileum,P<0.001. Na(+), K(+)-ATPase activity was significantly depressed only in the ileum,P<0.001. These changes were associated with a marked reduction in villous height, suggesting that the diarrhea could be an osmotic diarrhea due to nutrient (carbohydrate) malabsorption. Fresh stool samples were obtained and analyzed immediately for NA(+),K(+), osmolarity, glucose, and lactose; the osmotic gap was also determined. Stool osmolarity continually increased from 248±20 mosm/liter prior to inoculation to 348±20 mosm/liter at 75±1 hr postinoculation (P<0.005); the majority of the fecal osmotic gap could be accounted for by the amount of lactose present in the stools. Stool sodium increased from 34±6 mM prior to inoculation to a maximum of 65±4 mM at 53±1 hr postinoculation,P<0.001. There was no significant change in potassium concentration. The present investigation suggests that rotavirus-induced diarrhea is due to virus destruction of enterocytes lining the intestinal villi, thus reducing the mucosal surface area and important digestive enzymes. This destruction leads to an osmotic diarrhea due to nutrient (primarily carbohydrate) malabsorption. A possible contributing role of unopposed secretion from the crypt cannot be excluded from this study.
has issue date	1984-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01311255
bibo:pmid	6489082
has license	no-cc
sha1sum (hex)	c6d0e30e3d2f05eb8bc544bfe00b29e9afdee590
schema:url	https://doi.org/10.1007/bf01311255
resource representing a document's title	Pathogenesis of rotavirus-induced diarrhea: Preliminary studies in miniature swine piglet
has PubMed Central identifier	PMC7088308
has PubMed identifier	6489082
schema:publication	Dig Dis Sci
resource representing a document's body	covid:c6d0e30e3d2f05eb8bc544bfe00b29e9afdee590#body_text
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