About: Evolution of codon usage in Zika virus genomes is host and vector specific

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evolution of codon usage in Zika virus genomes is host and vector specific
Creator	Tong, Yigang Nasrullah, Izza Qamar, Raheel Mehmood Butt, Azeem
Source	Medline; PMC
abstract	The codon usage patterns of viruses reflect the evolutionary changes that allow them to optimize their survival and adapt their fitness to the external environment and, most importantly, their hosts. Here we report the genotype-specific codon usage patterns of Zika virus (ZIKV) strains from the current and previous outbreaks. Several genotype-specific and common codon usage traits were noted in the ZIKV coding sequences, indicating their independent evolutionary origins from a common ancestor. The overall influence of natural selection was more profound than that of mutation pressure, acting on a specific set of viral genes in the Asian-genotype ZIKV strains from the recent outbreak. An interplay between codon adaptation and deoptimization may have allowed the virus to adapt to multiple host and vectors and is reported for the first time in ZIKV genomes. Combining our codon analysis with geographical data on Aedes populations in the Americas suggested that ZIKV has evolved host- and vector-specific codon usage patterns to maintain successful replication and transmission chains within multiple hosts and vectors.
has issue date	2016-10-12(xsd:dateTime)
bibo:doi	10.1038/emi.2016.106
bibo:pmid	27729643
has license	cc-by
sha1sum (hex)	c6e2851ef1f6e35c2954eeaa913f2da2502842d9
schema:url	https://doi.org/10.1038/emi.2016.106
resource representing a document's title	Evolution of codon usage in Zika virus genomes is host and vector specific
has PubMed Central identifier	PMC5117728
has PubMed identifier	27729643
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:c6e2851ef1f6e35c2954eeaa913f2da2502842d9#body_text
is schema:about of	named entity 'strains' named entity 'replication' named entity 'strains' named entity 'host' named entity 'codon' named entity 'Zika virus' named entity 'ACTING' named entity 'ZIKA VIRUS' named entity 'TIME' named entity 'GENOTYPE' named entity 'CHANGES' named entity 'VECTORS' named entity 'AMERICAS' named entity 'SPECIFIC' named entity 'CODON USAGE' named entity 'INFLUENCE' named entity 'SET' named entity 'REPORT' named entity 'GENOMES' named entity 'NOTED' named entity 'A COMMON' named entity 'OVERALL' named entity 'HOSTS' named entity 'REFLECT' named entity 'POPULATIONS' named entity 'PROFOUND' named entity 'ANALYSIS' named entity 'ADAPTATION' named entity 'CODON' named entity 'VECTOR' named entity 'VIRUS' named entity 'OPTIMIZE' named entity 'CODON USAGE' named entity 'VIRAL GENES' named entity 'VECTOR' named entity 'SPECIFIC' named entity 'HOST' named entity 'AEDES' named entity 'SUCCESSFUL' named entity 'EXTERNAL' named entity 'FITNESS' named entity 'PATTERNS' named entity 'EVOLVED' named entity 'CODING' named entity 'HERE' named entity 'OUTBREAK' named entity 'INDICATING' named entity 'GENOMES' named entity 'TRAITS' named entity 'ENVIRONMENT' named entity 'INDEPENDENT' named entity 'REPLICATION' named entity 'REPORTED' named entity 'VIRUSES' named entity 'COMMON' named entity 'THEIR' named entity 'ASIAN' named entity 'CHAINS' named entity 'STRAINS' named entity 'SEQUENCES' named entity 'MUTATION' named entity 'RECENT' named entity 'COMBINING' named entity 'PREVIOUS' named entity 'HOST' named entity 'EVOLUTION' named entity 'ANCESTOR' named entity 'MULTIPLE' named entity 'OUTBREAKS' named entity 'PRESSURE' named entity 'TRANSMISSION' named entity 'OUR' named entity 'CURRENT' named entity 'GEOGRAPHICAL' named entity 'ADAPT' named entity 'ALLOW' named entity 'ORIGINS' named entity 'SURVIVAL'

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