About: SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

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About: SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
Creator	Sette, Alessandro Simmons, Graham Busch, Michael Franz, Sergej Miller, Christopher Tran, Nam Morrison, John Stone, Mars Carroll, Timothy Davis, U Deere, Jesse Dutra, Joseph Elizaldi, Sonny Hartigan-O'connor, Dennis Iyer, Smita Kozlowsk, Pamela Lakshmanappa, Ma, Zhong-Min Mcsorley, Stephen Nguyen, Nancy Olstad, Katherine Reader, J Roh, Jamin Sammak, Rebecca Schmidt, Brian Smith, Justin Usachenko, Jodie Van Rompay, Koen Watanabe, Jennifer Weaver, Kourtney Weiskopf, Daniela Yashavanth, Shaan Yee, Joann
source	Medline; PMC
abstract	CD4 T follicular helper (T (fh) ) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T (fh) cells and stimulates the germinal center response is an important question as we investigate vaccine options for the current pandemic. Here we report that SARS-CoV-2 infection resulted in transient accumulation of pro-inflammatory monocytes and proliferating T (fh) cells with a T (h) 1 profile in peripheral blood. CD4 helper cell responses were skewed predominantly toward a T (h) 1 response in blood, lung, and lymph nodes. We observed the generation of germinal center T (fh) cells specific for the SARS-CoV-2 spike (S) and nucleocapsid (N) proteins, and a corresponding early appearance of antiviral serum IgG antibodies. Our data suggest that a vaccine promoting T (h) 1-type T (fh) responses that target the S protein may lead to protective immunity.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.21203/rs.3.rs-51545/v1
bibo:pmid	32818217
has license	cc-by
sha1sum (hex)	c74627e84167b9b8e25da393c806a90694aa797a
schema:url	https://doi.org/10.21203/rs.3.rs-51545/v1
resource representing a document's title	SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
has PubMed Central identifier	PMC7430596
has PubMed identifier	32818217
schema:publication	Res Sq
resource representing a document's body	covid:c74627e84167b9b8e25da393c806a90694aa797a#body_text
is schema:about of	named entity 'observed' named entity 'generates' named entity 'IgG' named entity 'cells' named entity 'speci' named entity 'induces' named entity 'IGG' named entity 'TYPE' named entity 'PRO' named entity 'MONOCYTES' named entity 'S PROTEIN' named entity 'ANTIVIRAL' named entity 'RESPONSE' named entity 'RESPONSE IN BLOOD' named entity 'CELLS' named entity 'OPTIONS' named entity 'CD4' named entity 'PROLIFERATING' named entity 'SARS-COV-2 INFECTION' named entity 'immunity' named entity 'cells' named entity 'degree' named entity 'cells' named entity 'lung' named entity 'lymph nodes' named entity 'infection' named entity 'humoral' named entity 'CD4' named entity 'SARS-CoV-2' named entity 'lung' named entity 'antiviral' named entity 'germinal center' named entity 'germinal center' named entity 'innate immune' named entity 'avidin' named entity 'FlowJo' named entity 'IgA antibodies' named entity 'germinal center' named entity 'CD4 T cell' named entity 'virus' named entity 'FDCs' named entity 'RBD' named entity 'dialyzed' named entity 'lung' named entity 'Phenotype' named entity 'spleen' named entity 'SARS-CoV-2' named entity 'antibody' named entity 'spleen'

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