About: Inflammatory response in mixed viral-bacterial community-acquired pneumonia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inflammatory response in mixed viral-bacterial community-acquired pneumonia
Creator	Torres, Antoni Bello, Salvador Fandos, Sergio Lapresta, Carlos Menendez, Rosario Mincholé, Elisa Panadero, Carolina Lasierra, Ana Ruiz, María Simon, Ana
Source	Medline; PMC
abstract	BACKGROUND: The role of mixed pneumonia (virus + bacteria) in community-acquired pneumonia (CAP) has been described in recent years. However, it is not known whether the systemic inflammatory profile is different compared to monomicrobial CAP. We wanted to investigate this profile of mixed viral-bacterial infection and to compare it to monomicrobial bacterial or viral CAP. METHODS: We measured baseline serum procalcitonin (PCT), C reactive protein (CRP), and white blood cell (WBC) count in 171 patients with CAP with definite etiology admitted to a tertiary hospital: 59 (34.5%) bacterial, 66 (39.%) viral and 46 (27%) mixed (viral-bacterial). RESULTS: Serum PCT levels were higher in mixed and bacterial CAP compared to viral CAP. CRP levels were higher in mixed CAP compared to the other groups. CRP was independently associated with mixed CAP. CRP levels below 26 mg/dL were indicative of an etiology other than mixed in 83% of cases, but the positive predictive value was 45%. PCT levels over 2.10 ng/mL had a positive predictive value for bacterial-involved CAP versus viral CAP of 78%, but the negative predictive value was 48%. CONCLUSIONS: Mixed CAP has a different inflammatory pattern compared to bacterial or viral CAP. High CRP levels may be useful for clinicians to suspect mixed CAP.
has issue date	2014-07-29(xsd:dateTime)
bibo:doi	10.1186/1471-2466-14-123
bibo:pmid	25073709
has license	cc-by
sha1sum (hex)	c83a4991d36a6086da50b13968955329c5f07a6c
schema:url	https://doi.org/10.1186/1471-2466-14-123
resource representing a document's title	Inflammatory response in mixed viral-bacterial community-acquired pneumonia
has PubMed Central identifier	PMC4118651
has PubMed identifier	25073709
schema:publication	BMC Pulm Med
resource representing a document's body	covid:c83a4991d36a6086da50b13968955329c5f07a6c#body_text
is schema:about of	named entity 'INFLAMMATORY RESPONSE' named entity 'BACKGROUND' named entity 'VIRAL' named entity 'WHITE BLOOD CELL' named entity 'DIFFERENT' named entity 'BASELINE' named entity 'YEARS' covid:arg/c83a4991d36a6086da50b13968955329c5f07a6c named entity 'INFLAMMATORY' named entity 'WANTED' named entity 'ETIOLOGY' named entity 'TERTIARY' named entity 'BACTERIAL INFECTION' named entity 'DESCRIBED' named entity 'PATIENTS' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'TO INVESTIGATE' named entity 'VIRAL-' named entity 'MIXED' named entity 'ROLE' named entity 'SYSTEMIC' named entity 'METHODS' named entity 'NOT KNOWN' named entity 'VIRAL AND' named entity 'SERUM' named entity 'COUNT' named entity 'COMPARED' named entity 'TO COMPARE' named entity 'C REACTIVE PROTEIN' named entity 'ADMITTED TO' named entity 'PROTEIN ' named entity 'VIRAL-' named entity 'PROCALCITONIN' named entity 'PROFILE' named entity 'MEASURED' named entity 'BACTERIAL' named entity 'DEFINITE' named entity 'RECENT' named entity 'MIXED' named entity 'BACTERIA' named entity 'BACTERIAL COMMUNITY' named entity 'CAP' named entity 'HOSPITAL' named entity 'PNEUMONIA' named entity 'WBC' named entity 'bacterial' named entity 'compare' named entity 'community-acquired pneumonia' named entity 'CAP' named entity 'protein' named entity 'systemic inflammatory' named entity 'community-acquired pneumonia' named entity 'Inflammatory response' named entity 'measured' named entity 'influenza vaccination' named entity 'OC43' named entity 'asymptomatic' named entity 'pathogen' named entity 'upper airway infection' named entity 'Virus' named entity 'serological' named entity 'virus' named entity 'Adenovirus' named entity 'etiology' named entity 'bacteria' named entity 'Sputum' named entity 'Serum' named entity 'Human metapneumovirus' named entity 'neutropenia' named entity 'CRP' named entity '229E'

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