About: Vaccine-Induced Th1-Type Response Protects against Invasive Group A Streptococcus Infection in the Absence of Opsonizing Antibodies

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About: Vaccine-Induced Th1-Type Response Protects against Invasive Group A Streptococcus Infection in the Absence of Opsonizing Antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Vaccine-Induced Th1-Type Response Protects against Invasive Group A Streptococcus Infection in the Absence of Opsonizing Antibodies
Creator	Petrovsky, Nikolai Goldblatt, David Brunner, Livia Collin, Nicolas Jones, Scott Lawrenz, Maria Richter, Johanna Rivera-Hernandez, Tania Segui-Perez, Celia Kaufmann, Stefan Cork, Amanda Rhyme, Mira Walker, Mark
source	PMC
abstract	Recent global advocacy efforts have highlighted the importance of development of a vaccine against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that provides protection against GAS skin infection in mice and reduces the severity of pharyngitis in nonhuman primates. However, Combo5 with the addition of aluminum hydroxide (alum) as an adjuvant failed to protect against invasive GAS infection of mice. Here, we show that formulation of Combo5 with adjuvants containing saponin QS21 significantly improves protective efficacy, even though all 7 adjuvants tested generated high antigen-specific IgG antibody titers, including alum. Detailed characterization of Combo5 formulated with SMQ adjuvant, a squalene-in-water emulsion containing a TLR4 agonist and QS21, showed significant differences from the results obtained with alum in IgG subclasses generated following immunization, with an absence of GAS opsonizing antibodies. SMQ, but not alum, generated strong interleukin-6 (IL-6), gamma interferon (IFN-γ), and tumor necrosis alpha (TNF-α) responses. This work highlights the importance of adjuvant selection for non-M protein-based GAS vaccines to optimize immune responses and protective efficacy.
has issue date	2020-03-10(xsd:dateTime)
bibo:doi	10.1128/mbio.00122-20
bibo:pmid	32156809
has license	cc-by
sha1sum (hex)	c95bc52314489ac00018c205dd17e5250f361d2b
schema:url	https://doi.org/10.1128/mbio.00122-20
resource representing a document's title	Vaccine-Induced Th1-Type Response Protects against Invasive Group A Streptococcus Infection in the Absence of Opsonizing Antibodies
has PubMed Central identifier	PMC7064752
has PubMed identifier	32156809
schema:publication	mBio
resource representing a document's body	covid:c95bc52314489ac00018c205dd17e5250f361d2b#body_text
is schema:about of	named entity 'INDUCED' named entity 'IgG' named entity 'vaccine' named entity 'adjuvant' named entity 'vaccine' named entity 'Here' named entity 'adjuvants' named entity 'Invasive' named entity 'BUT' named entity 'TESTED' named entity 'NOVEL' named entity 'GLOBAL' named entity '90%' named entity 'SELECTION' named entity 'DISEASE MODEL' named entity 'ABSENCE OF' named entity 'SIGNIFICANT' named entity 'HAVE' named entity 'OVERALL' named entity 'TLR4' named entity 'FOLLOWING' named entity 'ADVOCACY' named entity 'WATER' named entity 'INTERLEUKIN-6 ' named entity 'A GROUP' named entity 'AVAILABILITY OF' named entity 'GAS INFECTION' named entity 'MICE' named entity 'RESULTS' named entity 'IGG SUBCLASSES' named entity 'PHARYNGITIS' named entity 'PUBLIC HEALTH' named entity 'DETAILED' named entity 'MEDIATED' named entity 'STRONG' named entity 'RECENT' named entity 'ALPHA' named entity 'EFFICACY' named entity 'NON-' named entity 'EMULSION' named entity 'BASED' named entity 'INFECTION' named entity 'HERE' named entity 'HIGH' named entity 'MAY BE' named entity 'PROTECTION' named entity 'HEALTH NEED' named entity 'TUMOR NECROSIS' named entity 'PROVIDES' named entity 'ANTIGENS' named entity 'SAPONIN' named entity 'CHARACTERIZATION' named entity 'INVASIVE DISEASE' named entity 'INTERFERON ' named entity 'M PROTEIN' named entity 'IMMUNE RESPONSES' named entity 'GENERATED' named entity 'VACCINE' named entity 'ANTIGEN' named entity 'INFECTIONS' named entity 'TH1' covid:arg/c95bc52314489ac00018c205dd17e5250f361d2b named entity 'PROVIDE' named entity 'CONTAINING' named entity 'IMMUNE RESPONSE' named entity 'ANTIBODY TITERS' named entity 'INVASIVE' named entity 'RESPONSE' named entity 'TYPE'

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