About: BAG3: a multifaceted protein that regulates major cell pathways

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About: BAG3: a multifaceted protein that regulates major cell pathways Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	BAG3: a multifaceted protein that regulates major cell pathways
Creator	De Laurenzi, V Graziano, V Pascale, M Rosati, A Turco, M
Source	Medline; PMC
abstract	Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through BAG domain (110–124 amino acids). BAG3 is the only member of the family to be induced by stressful stimuli, mainly through the activity of heat shock factor 1 on bag3 gene promoter. In addition to the BAG domain, BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70. These multifaceted interactions underlie BAG3 ability to modulate major biological processes, that is, apoptosis, development, cytoskeleton organization and autophagy, thereby mediating cell adaptive responses to stressful stimuli. In normal cells, BAG3 is constitutively present in a very few cell types, including cardiomyocytes and skeletal muscle cells, in which the protein appears to contribute to cell resistance to mechanical stress. A growing body of evidence indicate that BAG3 is instead expressed in several tumor types. In different tumor contexts, BAG3 protein was reported to sustain cell survival, resistance to therapy, and/or motility and metastatization. In some tumor types, down-modulation of BAG3 levels was shown, as a proof-of-principle, to inhibit neoplastic cell growth in animal models. This review attempts to outline the emerging mechanisms that can underlie some of the biological activities of the protein, focusing on implications in tumor progression.
has issue date	2011-04-07(xsd:dateTime)
bibo:doi	10.1038/cddis.2011.24
bibo:pmid	21472004
has license	cc-by-nc-nd
sha1sum (hex)	ca8b14f351edca29473646f4bb9669c3ad03500c
schema:url	https://doi.org/10.1038/cddis.2011.24
resource representing a document's title	BAG3: a multifaceted protein that regulates major cell pathways
has PubMed Central identifier	PMC3122056
has PubMed identifier	21472004
schema:publication	Cell Death Dis
resource representing a document's body	covid:ca8b14f351edca29473646f4bb9669c3ad03500c#body_text
is schema:about of	named entity 'PROTEIN ' named entity 'OF-' named entity 'DOMAIN' named entity 'FOCUSING' named entity 'MECHANISMS' named entity 'OUTLINE' named entity '124' named entity 'CARDIOMYOCYTES' named entity 'REPORTED' named entity 'THESE' named entity 'ANIMAL MODELS' named entity 'STIMULI' named entity 'MODULATION' named entity 'MULTIFACETED' named entity 'CELL TYPES' named entity 'OF EVIDENCE' named entity 'IS A' named entity 'MECHANICAL STRESS' named entity 'STRESSFUL' named entity 'BIOLOGICAL PROCESSES' named entity 'MEDIATE' named entity 'TYPES' named entity 'HEAT SHOCK' named entity 'BAG' named entity 'CONTAINS' named entity 'NEOPLASTIC CELL' named entity 'ADDITION' named entity 'SUSTAIN' named entity 'CELL GROWTH' named entity 'stressful' named entity 'BAG3' named entity 'stimuli' named entity 'BCL2-ASSOCIATED ATHANOGENE 3' named entity 'CONTRIBUTE ' named entity '28110' named entity 'MULTIFACETED' named entity 'CELLS' named entity 'RICH' named entity 'CYTOSKELETON ORGANIZATION' named entity 'NORMAL' named entity 'RESISTANCE TO' named entity 'DEVELOPMENT' named entity 'AUTOPHAGY' named entity 'FAMILY' named entity 'DIFFERENT' named entity 'CELL' named entity 'MAJOR' named entity 'INTERACTIONS' named entity 'CELL' named entity 'TUMOR PROGRESSION' named entity 'PRINCIPLE' named entity 'ADAPTIVE' named entity 'ACTIVITIES' named entity 'MEMBER OF' named entity 'MAJOR' named entity 'APOPTOSIS' named entity 'PROTEIN ' named entity 'GENE PROMOTER' named entity 'PARTNERS' named entity 'PATHWAYS' named entity 'BAG3' named entity 'REPEAT' named entity 'GROWING' named entity 'PRESENT' named entity 'PROTEIN' named entity 'REVIEW' named entity 'MODULATE' named entity 'SKELETAL MUSCLE CELLS' named entity 'LEVELS' named entity 'PROLINE' named entity 'TO INHIBIT' named entity 'BINDING' named entity 'MOTILITY' named entity 'BAG3' named entity 'THERAPY' named entity 'CONTEXTS' named entity 'HEAT SHOCK PROTEIN'

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