About: Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

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About: Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile
Creator	Ding, Yan Zhao, Lei Wang, Yao Chen, Zhi-Lin Huang, Juan Liu, Pan Qin, Huan Xiong, Xiao-Li Zhang, Ling-Ling Zhou, Li-Shan Chen, Guoxun Lu, Binan Peng, Jinyong Tao, Xufeng Xiong, X-L Zhang, Zhou L-S
source	PMC
abstract	AIM: Bile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis. METHODS: Cell and animal experiments were given different concentrations of emodin. The BSEP upstream molecule farnesoid X receptor was down-regulated by small interfering RNA (siRNA) technology or guggulsterones and up-regulated by lentivirus or GW4064. Real-time PCR and Western blotting was employed to detect the mRNA and protein levels of BSEP in LO2 cell, rat primary hepatocytes and liver tissue. Immunohistochemistry (IHC) was used to examine the expression of BSEP in liver tissues. Rat liver function and pathological changes of liver tissue were performed by biochemical test and hematoxylin and eosin (HE) staining. RESULTS: Emodin could increase the mRNA and protein expression of BSEP and FXR. When down-regulating farnesoid X receptor expression with the siRNA or inhibitor guggulsterones, and up-regulating farnesoid X receptor expression with the lentivirus or agonist GW4064, emodin could increase the mRNA level of BSEP and FXR and the protein level of BSEP, FXR1, and FXR2. Emodin also had a notable effect on rat primary hepatocytes experiment, rat pathological manifestation, BSEP, FXR1, and FXR2 positive staining in liver tissues and the test of liver function. CONCLUSION: Emodin has a protective effect and a rescue activity on cholestasis via stimulating FXR/BSEP pathways in promoting the canalicular export of accumulated bile.
has issue date	2019-05-22(xsd:dateTime)
bibo:doi	10.3389/fphar.2019.00522
bibo:pmid	31191298
has license	cc-by
sha1sum (hex)	cc0396cb510d6413b537440d00ce0bf51abda136
schema:url	https://doi.org/10.3389/fphar.2019.00522
resource representing a document's title	Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile
has PubMed Central identifier	PMC6540617
has PubMed identifier	31191298
schema:publication	Front Pharmacol
resource representing a document's body	covid:cc0396cb510d6413b537440d00ce0bf51abda136#body_text
is schema:about of	named entity 'HAVE' named entity 'EXPORT' named entity 'BILE ACID' named entity 'BILE' named entity 'Cholestasis' named entity 'EMODIN' named entity 'CANALICULAR' named entity 'INTRAHEPATIC CHOLESTASIS' named entity 'IMPORTANT' named entity 'SIGNALING PATHWAY' named entity 'INVESTIGATED' named entity 'CONFIRMED' named entity 'ACCUMULATED' covid:arg/cc0396cb510d6413b537440d00ce0bf51abda136 named entity 'PATHWAY' named entity 'FXR' named entity 'PROMOTING' named entity 'EXPORT' named entity 'PLAY' named entity 'BSEP' named entity 'CANALICULAR' named entity 'BILE SALT EXPORT PUMP' named entity 'TREATMENT' named entity 'AIM' named entity 'CHOLESTASIS' named entity 'EFFECT' named entity 'ROLE' named entity 'STIMULATING' named entity 'STUDY' named entity 'EMODIN' named entity 'salt export' named entity 'bile acid' named entity 'BSEP' named entity 'Bile' named entity 'Intrahepatic Cholestasis' named entity 'FXR' named entity 'regulate the expression' named entity 'enhanced chemiluminescence' named entity 'triglycerides' named entity 'FXR' named entity 'TBIL' named entity 'SHP' named entity 'rat' named entity 'DXM' named entity 'emodin' named entity 'Student's t-test' named entity 'control group' named entity 'hepatocytes' named entity 'mRNA' named entity '0.01' named entity 'emodin' named entity '1:500' named entity 'IgG' named entity 'protein' named entity 'Emodin' named entity '0.01' named entity 'emodin' named entity 'RNA' named entity 'Cytotoxicity' named entity 'LO2' named entity 'guggulsterone' named entity 'heterodimer' named entity 'UDCA' named entity 'FXR' named entity 'emodin' named entity 'dose-response'

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