About: Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection
Creator	Cheng, Ching-Chang Chiu, Yung-Tsung Lee, Yen-Feng Lin, Nai-Nu Tung, Kwong-Chung Wu, Chieh-Liang
source	Medline; PMC
abstract	Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS), typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2) was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs), extracellular collagen matrix (ECM) deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased (P < .05). Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.
has issue date	2010-09-27(xsd:dateTime)
bibo:doi	10.1155/2011/245728
bibo:pmid	20976305
has license	no-cc
sha1sum (hex)	cc2e7594049d91279f4e3d69d27b440ddd8de1f9
schema:url	https://doi.org/10.1155/2011/245728
resource representing a document's title	Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection
has PubMed Central identifier	PMC2952812
has PubMed identifier	20976305
schema:publication	J Biomed Biotechnol
resource representing a document's body	covid:cc2e7594049d91279f4e3d69d27b440ddd8de1f9#body_text
is schema:about of	named entity 'Porcine' named entity 'correlative' named entity 'bronchopneumonia' named entity 'animal model' named entity 'molecules' named entity 'chronic respiratory disease' named entity 'typical' named entity 'lungs' named entity 'typical' named entity 'Porcine' named entity 'SWINE' named entity 'BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'INCREASED' named entity 'SAMPLES' named entity '28P' named entity 'ACTIVE' named entity 'PIGS' named entity 'THESE' named entity 'ANIMAL MODEL' named entity 'MOLECULAR' named entity 'MOLECULES' named entity 'INFER' named entity 'INSTANCE' named entity 'PNEUMOCYTES' named entity 'COLLAGEN MATRIX' named entity 'IS A' named entity 'POLYPOID' named entity 'HUMAN' named entity 'NATURAL' named entity 'OUR' named entity 'PROLIFERATION' named entity 'LESION' named entity 'TYPE II' named entity 'PATHOLOGIC FINDINGS' named entity 'STEROIDS' named entity 'MYOFIBROBLASTS' named entity 'GELATINASE' named entity 'WAY' named entity 'PORCINE' named entity 'THEIR' named entity 'BRONCHOPNEUMONIA' named entity 'FRAGMENTATION' named entity 'MIGRATION' named entity 'CONVENIENT' named entity 'MARGINAL' named entity 'LEADS' named entity 'SIMILAR' named entity 'AREA' named entity 'LESIONS' covid:arg/cc2e7594049d91279f4e3d69d27b440ddd8de1f9 named entity 'CONSIDERED' named entity 'TYPICAL' named entity 'CONSTITUENTS' named entity 'ASSOCIATED WITH' named entity 'PERSISTENT INFECTION' named entity 'PATHOGENESIS' named entity 'DEPOSITION' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'BOOP' named entity 'IDENTIFIED' named entity 'MECHANISMS' named entity 'ELASTIC FIBERS' named entity 'OSTEOPONTIN' named entity 'VIRAL INFECTION' named entity 'GELATINASE A' named entity 'REVEALED' named entity 'FIBROTIC' named entity 'UNDERSTOOD' named entity 'INTRALUMINAL' named entity 'CHRONIC RESPIRATORY DISEASE' named entity 'LEVEL' named entity 'ACTIVITY' named entity 'SWINE' named entity 'LUNGS' named entity 'OBTAIN'

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