About: Association of Interleukin-8 and Neutrophils with Nasal Symptom Severity During Acute Respiratory Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of Interleukin-8 and Neutrophils with Nasal Symptom Severity During Acute Respiratory Infection
Creator	Barrett, Bruce Xie, Yaoguo Zhang, Zhengjun Hayney, Mary Henriquez, Kelsey
source	Medline; PMC
abstract	Using a large data set (n = 811), the relationship between acute respiratory infection illness severity and inflammatory biomarkers was investigated to determine whether certain symptoms are correlated more closely than others with the inflammatory biomarkers, interleukin-8 (IL-8) and nasal neutrophils. Participants with community acquired acute respiratory infection underwent nasal lavage for IL-8 and neutrophil testing, in addition to multiplex polymerase chain reaction (PCR) methods for the detection and identification of respiratory viruses. Information about symptoms was obtained throughout the duration of the illness episode using the well-validated Wisconsin Upper Respiratory Symptom Survey (WURSS-21). Global symptom severity was calculated by the area under the curve (AUC) plotting duration versus WURSS total. Of the specimens tested, 56% were positively identified for one or more of nine different respiratory viruses. During acute respiratory infection illness, both IL-8 and neutrophils positively correlate with AUC (r(s) = 0.082, P = 0.022; r(s) = 0.080, P = 0.030). IL-8 and neutrophils correlate with nasal symptom severity: runny nose (r = 0.13, P = <0.00001; r = 0.18, P = <0.003), plugged nose (r = 0.045, P = 0.003; r = 0.14, P = 0.058), and sneezing (r = −0.02, P = <0.0001; r = −0.0055, P = 0.31). Neutrophils correlate with some quality of life measures such as sleeping well (r = 0.15, P = 0.026). Thus, the study demonstrates that IL-8 and neutrophils are correlated with severity of nasal symptoms during acute respiratory infection. Further research is necessary to determine if the concentration of these or other biomarkers can predict the overall duration and severity of acute respiratory infection illness.
has issue date	2014-08-17(xsd:dateTime)
bibo:doi	10.1002/jmv.24042
bibo:pmid	25132248
has license	green-oa
sha1sum (hex)	ce959dfce0605c25ac5acc75537fcdfacb3f9072
schema:url	https://doi.org/10.1002/jmv.24042
resource representing a document's title	Association of Interleukin-8 and Neutrophils with Nasal Symptom Severity During Acute Respiratory Infection
has PubMed Central identifier	PMC4348013
has PubMed identifier	25132248
schema:publication	Journal of Medical Virology
resource representing a document's body	covid:ce959dfce0605c25ac5acc75537fcdfacb3f9072#body_text
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