About: Myocardial injury characterized by elevated cardiac troponin and in‐hospital mortality of COVID‐19: an insight from a meta‐analysis

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About: Myocardial injury characterized by elevated cardiac troponin and in‐hospital mortality of COVID‐19: an insight from a meta‐analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Myocardial injury characterized by elevated cardiac troponin and in‐hospital mortality of COVID‐19: an insight from a meta‐analysis
Creator	Ishikawa, Kiyotake Kuno, Toshiki Takagi, Hisato Aikawa, Tadao
Source	Medline; PMC
abstract	Elevation of high‐sensitivity cardiac troponin (hs‐cTn) is a surrogate of myocardial injury, which appears to be a common complication of coronavirus disease 2019 (COVID‐19). In this study, a meta‐analysis was performed to clarify the association between myocardial injury assessed by hs‐cTn levels and in‐hospital mortality in patients with COVID‐19. All existing studies on myocardial injury in patients with COVID‐19 were retrieved from PubMed and EMBASE through April 13, 2020. In cases where overlap of the study population or enrollment period was found in articles published from the same hospitals, the article with the largest number of patients was only included in the analysis. The pooled odds ratio was calculated using inverse variance weighted random‐effects models. Six observational studies which included a total of 1,231 patients met the search criteria. The percentage of patients with hs‐cTn levels varied across the studies (13‐41%). Elevated hs‐cTn levels were significantly associated with an increase in in‐hospital mortality (pooled odds ratio, 22.7; 95% confidence interval, 13.6‐38.1; P<0.001) with a moderate heterogeneity (I (2)=28%), suggesting that elevated hs‐cTn levels might be used as a reliable marker of disease severity early in the course of COVID‐19. This article is protected by copyright. All rights reserved.
has issue date	2020-06-02(xsd:dateTime)
bibo:doi	10.1002/jmv.26108
bibo:pmid	32484975
has license	no-cc
sha1sum (hex)	ced1e28a3735c2e8984c36fec0c1eea4a6e3d780
schema:url	https://doi.org/10.1002/jmv.26108
resource representing a document's title	Myocardial injury characterized by elevated cardiac troponin and in‐hospital mortality of COVID‐19: an insight from a meta‐analysis
has PubMed Central identifier	PMC7301031
has PubMed identifier	32484975
schema:publication	J Med Virol
resource representing a document's body	covid:ced1e28a3735c2e8984c36fec0c1eea4a6e3d780#body_text
is schema:about of	named entity 'injury' named entity 'search criteria' named entity 'patients' named entity 'EARLY' named entity 'ANALYSIS' named entity 'EFFECTS' named entity 'HS-' named entity 'CTN' named entity 'HOSPITALS' named entity 'MODERATE' named entity 'LARGEST' named entity 'ACROSS' named entity 'USING' named entity 'articles' named entity 'existing' named entity 'period' named entity 'injury' named entity 'mortality' named entity 'models' named entity 'Elevated' named entity 'levels' named entity 'Elevation' named entity 'meta-analysis' named entity 'Myocardial' named entity 'EMBASE' named entity 'coronavirus disease 2019' named entity 'observational studies' named entity 'study population' named entity 'myocardial injury' named entity 'meta-analysis' named entity 'COVID-19' named entity 'meta-analysis' named entity 'troponin' named entity 'clinical features' named entity 'myocardial injury' named entity 'COVID-19' named entity 'COVID' named entity 'COVID' named entity 'cTn' named entity 'COVID' named entity 'CK-MB' named entity 'COVID' named entity 'cardiovascular diseases' named entity 'cell entry' named entity 'coronavirus' named entity 'older age' named entity 'biomarkers' named entity 'COVID' named entity 'meta-analyses' named entity 'COVID-19' named entity 'confounding factors' named entity 'SARS-CoV-2' named entity 'coronavirus' named entity 'myocardial infarction' named entity 'COVID' named entity 'peer-reviewed' named entity 'meta-analysis' named entity 'cardiac biomarkers' named entity 'Interleukin-6' named entity '5,000,000' named entity 'COVID' named entity 'May 22' named entity 'COVID' named entity 'COVID' named entity 'myocardial injury' named entity 'myocarditis' named entity 'troponin' named entity 'cardiovascular disease' named entity 'cytokines' named entity 'risk factors' named entity 'meta-analysis' named entity 'myocardial injury' named entity 'coronavirus disease 2019' named entity 'myocardial injury' named entity 'severe pneumonia' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'COVID'

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