About: Examining the relationship between household air pollution and infant microbial nasal carriage in a Ghanaian cohort

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About: Examining the relationship between household air pollution and infant microbial nasal carriage in a Ghanaian cohort Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Examining the relationship between household air pollution and infant microbial nasal carriage in a Ghanaian cohort
Creator	Tokarz, Rafal Quinn, Ashlinn Kinney, Patrick Ae-Ngibise, Kenneth Asante, Kwaku Carrión, Daniel Chillrud, Steven Iddrisu, Luisa Jack, Darby Kaali, Seyram Lee, Alison Owusu-Agyei, Seth Wylie, Blair Yawson, Abena
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Pneumonia, a leading cause of childhood mortality, is associated with household air pollution (HAP) exposure. Mechanisms between HAP and pneumonia are poorly understood, but studies suggest that HAP may increase the likelihood of bacterial, instead of viral, pneumonia. We assessed the relationship between HAP and infant microbial nasal carriage among 260 infants participating in the Ghana Randomized Air Pollution and Health Study (GRAPHS). METHODS: Data are from GRAPHS, a cluster-randomized controlled trial of cookstove interventions (improved biomass or LPG) versus the 3-stone (baseline) cookstove. Infants were surveyed for pneumonia during the first year of life and had routine personal exposure assessments. Nasopharyngeal swabs collected from pneumonia cases (n = 130) and healthy controls (n = 130) were analyzed for presence of 22 common respiratory microbes by MassTag polymerase chain reaction. Data analyses included intention-to-treat (ITT) comparisons of microbial species presence by study arm, and exposure-response relationships. RESULTS: In ITT analyses, 3-stone arm participants had a higher mean number of microbial species than the LPG (LPG: 2.71, 3-stone: 3.34, p < 0.0001, n = 260). This difference was driven by increased bacterial (p < 0.0001) rather than viral species presence (non-significant). Results were pronounced in pneumonia cases and attenuated in healthy controls. Higher prevalence bacterial species were Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis. Exposure-response relationships did not yield significant associations between measured CO and nasal microbial carriage. CONCLUSIONS: Our intention-to-treat findings are consistent with a link between HAP and bacterial nasal carriage. No relationships were found for viral carriage. Given the null results in exposure-response analysis, it is likely that a pollutant besides CO is driving these differences.
has issue date	2019-09-10(xsd:dateTime)
bibo:doi	10.1016/j.envint.2019.105150
bibo:pmid	31518936
has license	no-cc
sha1sum (hex)	cf3d012a747aadc8d8756951bd68985c0589f45b
schema:url	https://doi.org/10.1016/j.envint.2019.105150
resource representing a document's title	Examining the relationship between household air pollution and infant microbial nasal carriage in a Ghanaian cohort
has PubMed Central identifier	PMC6868532
has PubMed identifier	31518936
schema:publication	Environ Int
resource representing a document's body	covid:cf3d012a747aadc8d8756951bd68985c0589f45b#body_text
is schema:about of	named entity 'INFANT' named entity 'HOUSEHOLD' named entity 'study' named entity 'arm' named entity 'consistent' named entity 'higher' named entity 'surveyed' named entity 'carriage' named entity 'INCLUDED' named entity 'MICROBIAL' named entity 'BACKGROUND' named entity 'UNDERSTOOD' named entity 'ANALYSIS' named entity 'CONCLUSIONS' named entity 'HEALTHY' named entity 'SIGNIFICANT' named entity 'NASAL' named entity 'COLLECTED' named entity 'DATA ANALYSES' named entity 'HIGHER' named entity 'DID' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'DRIVING' named entity 'INFANTS' named entity 'POLLUTANT' named entity 'RELATIONSHIPS' named entity 'HEALTH' named entity 'DIFFERENCE' named entity 'GIVEN' named entity 'POLYMERASE CHAIN REACTION' named entity 'ITT' named entity 'LIKELIHOOD' named entity 'NASAL' named entity 'BIOMASS' named entity 'RELATIONSHIP' named entity 'NUMBER OF' named entity 'RATHER' named entity 'ASSOCIATIONS' named entity 'GHANAIAN' named entity 'EXAMINING' named entity 'COHORT' named entity 'MICROBIAL' named entity 'BACTERIAL' named entity '260' named entity 'YEAR' named entity 'NASOPHARYNGEAL' named entity 'ASSESSMENTS' named entity 'CHILDHOOD' named entity 'LEADING' named entity 'INTERVENTIONS' named entity 'MORTALITY' named entity 'ATTENUATED' named entity 'SPECIES' named entity 'AIR POLLUTION' named entity 'METHODS' named entity 'RESPIRATORY' named entity 'PRESENCE OF' named entity 'ASSESSED' named entity 'LPG' named entity 'PRESENCE' named entity 'EXPOSURE' named entity 'BUT' named entity 'LINK' named entity 'SUGGEST' named entity 'MECHANISMS' named entity 'ANALYZED' named entity 'ROUTINE' named entity 'PERSONAL EXPOSURE'

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