About: Cellular microRNA miR-181b Inhibits Replication of Mink Enteritis Virus by Repression of Non-Structural Protein 1 Translation

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About: Cellular microRNA miR-181b Inhibits Replication of Mink Enteritis Virus by Repression of Non-Structural Protein 1 Translation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cellular microRNA miR-181b Inhibits Replication of Mink Enteritis Virus by Repression of Non-Structural Protein 1 Translation
Creator	Wang, D Li, S Yuan, J Wang, J-Z
source	PMC
abstract	Mink enteritis virus (MEV) is one of the most important viral pathogens in the mink industry. Recent studies have showed that microRNAs (miRNAs), small noncoding RNAs of length ranging from 18–23 nucleotides (nt) participate in host-pathogen interaction networks; however, whether or not miRNAs are involved in MEV infection has not been reported. Our study revealed that miRNA miR-181b inhibited replication of MEV in the feline kidney (F81) cell line by targeting the MEV non-structural protein 1 (NS1) messenger RNA (mRNA) coding region, resulting in NS1 translational repression, while MEV infection reduced miR-181b expression. This is the first description of cellular miRNAs modulating MEV infection in F81 cells, providing further insight into the mechanisms of viral infection, and may be useful in development of naturally-occurring miRNAs antiviral strategies.
has issue date	2013-12-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0081515
bibo:pmid	24349084
has license	cc-by
sha1sum (hex)	cf7837069ab6a12d5663c6f3c715b73fe53493a1
schema:url	https://doi.org/10.1371/journal.pone.0081515
resource representing a document's title	Cellular microRNA miR-181b Inhibits Replication of Mink Enteritis Virus by Repression of Non-Structural Protein 1 Translation
has PubMed Central identifier	PMC3859502
has PubMed identifier	24349084
schema:publication	PLoS One
resource representing a document's body	covid:cf7837069ab6a12d5663c6f3c715b73fe53493a1#body_text
is schema:about of	named entity 'MESSENGER RNA' named entity 'KIDNEY' named entity 'NS1' named entity 'NETWORKS' named entity 'MICRORNA' named entity 'VIRAL PATHOGENS' named entity 'FELINE' named entity 'OUR' named entity 'INFECTION' named entity 'TARGETING' named entity 'MINK ENTERITIS VIRUS' named entity 'VIRAL INFECTION' named entity 'MIR-181B' named entity 'MAY BE' named entity 'NON-STRUCTURAL PROTEIN 1' named entity 'TRANSLATION' named entity 'PROVIDING' named entity 'REPLICATION' named entity 'MIR-181B' named entity 'CELLULAR' named entity 'REVEALED' named entity 'LENGTH' named entity 'CELLULAR' named entity 'REDUCED' named entity 'ANTIVIRAL' named entity 'ONE OF' named entity 'MIRNAS' named entity 'INTERACTION' named entity 'STUDY' named entity 'RESULTING IN' named entity 'TRANSLATIONAL REPRESSION' named entity 'INHIBITED' named entity 'STRATEGIES' named entity 'MECHANISMS' named entity 'RNAS' named entity 'MINK' named entity 'IMPORTANT' named entity 'SMALL' named entity 'STUDIES' named entity 'MODULATING' named entity 'F81' named entity 'MICRORNAS' named entity 'MIRNA' named entity 'EXPRESSION' named entity 'CELLS' named entity 'DESCRIPTION' named entity 'CODING REGION' named entity 'INVOLVED' named entity 'RECENT' named entity 'INDUSTRY' named entity 'INSIGHT' named entity 'HAVE' named entity 'MEV' named entity 'REPLICATION' named entity 'REPRESSION' named entity 'NON-STRUCTURAL PROTEIN 1' named entity 'MINK ENTERITIS VIRUS' named entity 'USEFUL' named entity 'CELL LINE' named entity 'DEVELOPMENT' named entity 'NUCLEOTIDES' named entity 'REPORTED' named entity 'NS1' named entity 'miRNAs' named entity 'miRNAs' named entity 'small noncoding RNAs' named entity 'coding region' named entity 'mRNA' named entity 'infection' named entity 'MEV' named entity 'miR' named entity 'infection' named entity 'Mink enteritis virus' named entity 'Non-Structural Protein' named entity 'Mink Enteritis' named entity 'BCL2' named entity 'PTEN' named entity 'MEV'

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