About: Epigenetic and epitranscriptomic regulation of viral replication

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Epigenetic and epitranscriptomic regulation of viral replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epigenetic and epitranscriptomic regulation of viral replication
Creator	Cullen, Bryan Tsai, Kevin
source	Medline; PMC
abstract	Eukaryotic gene expression is regulated not only by genomic enhancers and promoters, but also by covalent modifications added to both chromatin and RNAs. Whereas cellular gene expression may be either enhanced or inhibited by specific epigenetic modifications deposited on histones (in particular, histone H3), these epigenetic modifications can also repress viral gene expression, potentially functioning as a potent antiviral innate immune response in DNA virus-infected cells. However, viruses have evolved countermeasures that prevent the epigenetic silencing of their genes during lytic replication, and they can also take advantage of epigenetic silencing to establish latent infections. By contrast, the various covalent modifications added to RNAs, termed epitranscriptomic modifications, can positively regulate mRNA translation and/or stability, and both DNA and RNA viruses have evolved to utilize epitranscriptomic modifications as a means to maximize viral gene expression. As a consequence, both chromatin and RNA modifications could serve as novel targets for the development of antivirals. In this Review, we discuss how host epigenetic and epitranscriptomic processes regulate viral gene expression at the levels of chromatin and RNA function, respectively, and explore how viruses modify, avoid or utilize these processes in order to regulate viral gene expression.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1038/s41579-020-0382-3
bibo:pmid	32533130
has license	no-cc
sha1sum (hex)	cf937b0c24736decd005c1e457ca0540dcc0628b
schema:url	https://doi.org/10.1038/s41579-020-0382-3
resource representing a document's title	Epigenetic and epitranscriptomic regulation of viral replication
has PubMed Central identifier	PMC7291935
has PubMed identifier	32533130
schema:publication	Nat Rev Microbiol
resource representing a document's body	covid:cf937b0c24736decd005c1e457ca0540dcc0628b#body_text
is schema:about of	named entity 'chromatin' named entity 'regulated' named entity 'antiviral' named entity 'histone H3' named entity 'expression' named entity 'STABILITY' named entity 'RNA MODIFICATIONS' named entity 'evolved' named entity 'covalent' named entity 'viruses' named entity 'deposited' named entity 'genes' named entity 'viral' named entity 'infections' named entity 'viruses' named entity 'gene' named entity 'epigenetic modifications' named entity 'gene expression is regulated' named entity 'chromatin' named entity 'epigenetic modifications' named entity 'gene expression' named entity 'gene expression' named entity 'viruses' named entity 'DNA virus' named entity 'RNA' named entity 'epigenetic silencing' named entity 'epitranscriptomic' named entity 'epitranscriptomic' named entity 'Microbiology' named entity 'enhanced' named entity 'KSHV' named entity 'viral RNA sensors' named entity 'RNA' named entity 'epigenetic' named entity 'codons' named entity 'eukaryotic' named entity 'heterochromatin' named entity 'HIV-1' named entity 'chromatin' named entity 'repressor' named entity 'gene regulation' named entity 'ribose' named entity 'viruses' named entity 'RNA' named entity 'epigenetic silencing' named entity 'viral particles' named entity 'proviral' named entity 'eukaryotic cells' named entity 'gene regulation' named entity 'lytic replication' named entity 'mammalian cells' named entity 'retrotransposons' named entity 'H3K9me3' named entity 'IRF3' named entity 'HIV-1' named entity 'wild-type' named entity 'RNA' named entity 'drug-resistant' named entity 'epitranscriptomic' named entity 'RNA' named entity 'SETDB1' named entity 'adenosine' named entity 'viruses' named entity 'ATRX' named entity 'antibodies' named entity 'YtHDF2' named entity 'retrovirus' named entity 'rNA' named entity 'viral DNA' named entity 'IFI16' named entity 'Kaposi sarcoma-associated herpesvirus' named entity 'herpesviruses' named entity 'antiviral' named entity 'gene expression' named entity 'infection' named entity 'viral proteins' named entity 'crosslinking' named entity 'obligate intracellular parasites' named entity 'rNase' named entity 'gene expression'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software