About: A clinical and biological framework on the role of visceral fat tissue and leptin in SARS-CoV-2 infection related respiratory failure

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About: A clinical and biological framework on the role of visceral fat tissue and leptin in SARS-CoV-2 infection related respiratory failure Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A clinical and biological framework on the role of visceral fat tissue and leptin in SARS-CoV-2 infection related respiratory failure
Creator	Knoester, Marjolein Hamming, Inge Calkhoven, Cornelis Hj Van Der Voort, Peter Moser, Jill Muller Kobold, Anneke Peter, H Van Der Voort, Van Meurs, Matijs Zandstra, Durk
Source	MedRxiv
abstract	Obesity is a risk factor for SARS-CoV-2 infected patients to develop respiratory failure. Leptin produced in visceral fat might play a role in the deterioration to mechanical ventilation. A cross sectional study was performed. The mean BMI was 31 kg/m2 (range 24.8-48.4) for the 31 SARS-CoV-2 ventilated patients and 26 kg/m2 (range 22.4-33.5) for the 8 controls. SARS-CoV-2 infected patients with a similar BMI as control patients appear to have significantly higher levels of serum leptin. The mean leptin level was 21.2 (6.0-85.2) vs 5.6 (2.4-8.2) ug/L for SARS-CoV-2 and controls respectively (p=0.0007). With these findings we designed a clinical and biological framework that explains clinical observations. The ACE2 utilization by the virus leads to local pulmonary inflammation due to ACE2-ATII disbalance. This is enhanced by an increase in leptin production induced by SARS-CoV-2 infection of visceral fat. Leptin receptors in the lungs are now more activated to enhance local pulmonary inflammation. This adds to the pre-existent chronic inflammation in obese patients. Visceral fat, lung tissue and leptin production play an interconnecting role. This insight can lead the way to further research and treatment.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.04.30.20086108
has license	medrxiv
sha1sum (hex)	d2562fe263a86bcda2a45dadd92405414201a6f4
schema:url	https://doi.org/10.1101/2020.04.30.20086108
resource representing a document's title	A clinical and biological framework on the role of visceral fat tissue and leptin in SARS-CoV-2 infection related respiratory failure
resource representing a document's body	covid:d2562fe263a86bcda2a45dadd92405414201a6f4#body_text
is schema:about of	named entity 'levels' named entity 'respiratory failure' named entity 'visceral fat' named entity 'RESEARCH' named entity 'DUE TO' named entity 'LOCAL' named entity 'LEAD' named entity 'VIRUS' named entity 'leptin' named entity 'play' named entity 'study' named entity 'patients' named entity 'local' named entity 'adds' named entity 'receptors' named entity 'infection' named entity 'control patients' named entity 'SARS-CoV-2' named entity 'Obesity' named entity 'Visceral fat' named entity 'virus' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'lung tissue' named entity 'respiratory failure' named entity 'visceral fat' named entity 'pro-inflammatory cytokine' named entity 'leptin' named entity 'BMI' named entity 'anosmia' named entity 'leptin' named entity 'serum' named entity 'medRxiv' named entity 'tachypnoea' named entity 'leptin' named entity 'BMI' named entity 'SARS-CoV2' named entity 'inflammatory response' named entity 'ACE2' named entity 'Acute Respiratory Distress Syndrome' named entity 'leptin' named entity 'SARS-CoV-2' named entity 'angiotensin converting enzyme 2' named entity 'ACE2' named entity 'ARDS' named entity 'ICU' named entity 'respiratory failure' named entity 'leptin' named entity 'ICU' named entity 'preprint' named entity 'proinflammatory cytokines' named entity 'necrosis' named entity 'adipose tissue' named entity 'SARS-CoV-2' named entity 'critically ill' named entity 'mechanical ventilation' named entity 'lungs' named entity 'vasodilation' named entity 'clinical characteristics' named entity 'peer review' named entity 'leptin' named entity 'ICU' named entity 'respiratory failure' named entity 'lung' named entity 'intensive care' named entity 'intestines' named entity 'dyspnea' named entity 'respiratory tract' named entity 'visceral fat' named entity 'hemodynamically' named entity 'Resveratrol' named entity 'blood glucose' named entity 'flu-like' named entity 'inflammation' named entity 'weight loss' named entity 'Spearman correlation'

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