About: Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue

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About: Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue
Creator	Schauer, Roland Vlasak, Reinhard Kohla, Guido Bauer, Hans-Christian Pons, Alexandre Richet, Colette Rinninger, Andreas Zanetta, Jean-Pierre Kohla, G Pons, A Richet, C Schauer, · Zanetta, J.-P
source	Medline; PMC
abstract	Infections by mouse hepatitis viruses result in disease of the liver, the gastrointestinal tract, respiratory tract, and the central nervous system. Coronaviruses related to mouse hepatitis virus express a hemagglutinin-esterase surface glycoprotein, which specifically hydrolyses either 5-N-acetyl-4-O-acetyl neuraminic acid (Neu4,5Ac(2)) or 5-N-acetyl-9-O-acetyl neuraminic acid (Neu5,9Ac(2)). Moreover, these sialic acids represent potential cellular receptor determinants for murine coronaviruses. Until now, the distribution of these sialic acids in mouse brain was not thoroughly investigated. Particularly Neu4,5Ac(2) was not yet found in mouse brain. Using a sensitive method of gas chromatography coupled to mass spectrometry in the electron impact mode of ionization this manuscript demonstrates the occurrence of 13 different sialic acids varying in their alkyl and acyl substituents in mouse tissues including 5-N-acetyl-4-O-acetyl-9-O-lactyl-neuraminic acid (Neu4,5Ac(2)9Lt), 5-N-acetyl-9-O-lactyl-neuraminic acid (Neu5Ac9Lt), 5-N-acetyl-8-O-methyl-neuraminic acid (Neu5Ac8Me) and the 1,7-lactone (Neu5Ac1,7L) of neuraminic acid. Neu4,5Ac(2), relatively abundant in the gut, was present as a minor compound in all tissues, including liver, olfactory lobe, telencephalon, metencephalon and hippocampus. Neu5,9Ac(2) was also found in these tissues, except in the liver. It is suggested that these sialic acids represent the endogenous substrate and receptor determinants for murine coronaviruses.
has issue date	2006-01-01(xsd:dateTime)
bibo:doi	10.1007/s10719-006-5439-7
bibo:pmid	16575524
has license	no-cc
sha1sum (hex)	d2d8b926deed3d673401f10a6d345c534259ae92
schema:url	https://doi.org/10.1007/s10719-006-5439-7
resource representing a document's title	Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue
has PubMed Central identifier	PMC7088067
has PubMed identifier	16575524
schema:publication	Glycoconj J
resource representing a document's body	covid:d2d8b926deed3d673401f10a6d345c534259ae92#body_text
is schema:about of	named entity 'receptor' named entity 'acid' named entity 'electron impact' named entity 'Infections' named entity 'tissue' named entity 'RECEPTOR' named entity 'GASTROINTESTINAL TRACT' named entity 'HEMAGGLUTININ' named entity 'NEU4' named entity 'USING' named entity 'IONIZATION' named entity 'RESULT' named entity 'MASS SPECTROMETRY' named entity 'ALKYL' named entity 'ACETYL' named entity 'TISSUES' named entity 'APPLIED' named entity 'N-ACETYL' covid:arg/d2d8b926deed3d673401f10a6d345c534259ae92 named entity 'ACETYLATED' named entity 'HEPATITIS VIRUSES' named entity 'LIVER' named entity 'INCLUDING' named entity 'DISTRIBUTION' named entity 'VARYING' named entity 'HEMAGGLUTININ' named entity 'LOCALISATION' named entity 'ESTERASES' named entity 'N-ACETYLNEURAMINIC ACIDS' named entity 'MURINE' named entity 'MOUSE' named entity 'CORONAVIRUSES' named entity 'TISSUE' named entity 'MOUSE BRAIN' named entity 'INVESTIGATED' named entity 'THOROUGHLY' named entity 'OCCURRENCE' named entity 'FOUND' named entity 'THEIR' named entity 'SENSITIVE' named entity 'RESPIRATORY TRACT' named entity 'CELLULAR' named entity 'DISEASE' named entity 'DISTRIBUTION' named entity 'ENDOGENOUS' named entity 'EITHER' named entity 'ESTERASE' named entity 'RELATED' named entity 'MOUSE' named entity 'EXPRESS' named entity 'MANUSCRIPT' named entity 'POTENTIAL' named entity 'DETERMINANTS' named entity 'THESE' named entity 'DIFFERENT' named entity 'MODE' named entity 'COUPLED' named entity 'CORONAVIRUSES' named entity 'BIOTECHNOLOGY' named entity 'METHOD' named entity 'MOUSE HEPATITIS' named entity 'INFECTIONS' named entity 'MURINE' named entity 'SIALIC ACIDS' named entity 'REPRESENT' named entity 'NEURAMINIC ACID' named entity 'GAS CHROMATOGRAPHY ' named entity 'MOUSE HEPATITIS VIRUS' named entity 'CENTRAL NERVOUS SYSTEM'

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