About: Association between Interferon Response and Protective Efficacy of NS1-Truncated Mutants as Influenza Vaccine Candidates in Chickens

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Association between Interferon Response and Protective Efficacy of NS1-Truncated Mutants as Influenza Vaccine Candidates in Chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between Interferon Response and Protective Efficacy of NS1-Truncated Mutants as Influenza Vaccine Candidates in Chickens
Creator	Jang, Hyesun Lee, Chang-Won Ngunjiri, John
Source	PMC
abstract	Influenza virus mutants that encode C-terminally truncated NS1 proteins (NS1-truncated mutants) are attractive candidates for avian live attenuated influenza vaccine (LAIV) development because they are both attenuated and immunogenic in chickens. We previously showed that a high protective efficacy of NS1-truncated LAIV in chickens corresponds with induction of high levels of type I interferon (IFN) responses in chicken embryonic fibroblast cells. In this study, we investigated the relationship between induction of IFN and IFN-stimulated gene responses in vivo and the immunogenicity and protective efficacy of NS1-truncated LAIV. Our data demonstrates that accelerated antibody induction and protective efficacy of NS1-truncated LAIV correlates well with upregulation of IFN-stimulated genes. Further, through oral administration of recombinant chicken IFN alpha in drinking water, we provide direct evidence that type I IFN can promote rapid induction of adaptive immune responses and protective efficacy of influenza vaccine in chickens.
has issue date	2016-06-03(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0156603
bibo:pmid	27257989
has license	cc-by
sha1sum (hex)	d38a164a0b254a96195ad1715929340f82cc110e
schema:url	https://doi.org/10.1371/journal.pone.0156603
resource representing a document's title	Association between Interferon Response and Protective Efficacy of NS1-Truncated Mutants as Influenza Vaccine Candidates in Chickens
has PubMed Central identifier	PMC4892592
has PubMed identifier	27257989
schema:publication	PLoS One
resource representing a document's body	covid:d38a164a0b254a96195ad1715929340f82cc110e#body_text
is schema:about of	named entity 'investigated' named entity 'truncated' named entity 'Influenza virus' named entity 'TRUNCATED' named entity 'INFLUENZA VIRUS' named entity 'INTERFERON ' named entity 'GENE' named entity 'NS1' named entity 'fibroblast' named entity 'embryonic' named entity 'recombinant' named entity 'adaptive immune responses' named entity 'Our' named entity 'avian' named entity 'NS1' named entity 'truncated' named entity 'development' named entity 'gene' named entity 'mutants' named entity 'recombinant' named entity 'NS1' named entity 'NS1' named entity 'fibroblast cells' named entity 'LAIV' named entity 'Influenza virus' named entity 'drinking water' named entity 'immunogenic' named entity 'LAIV' named entity 'mutants' named entity 'Influenza Vaccine' named entity 'NS1' named entity 'LAIV' named entity 'viral titers' named entity 'tissue culture' named entity 'inactivated vaccine' named entity 'inactivated vaccine' named entity 'adaptive immune responses' named entity 'gentamicin' named entity 'cell-mediated immunity' named entity 'vaccination' named entity 'transcription' named entity 'seroconversion' named entity 'chicken' named entity 'influenza vaccine' named entity 'cell cultures' named entity 'drinking water' named entity 'antibodies' named entity 'PBS' named entity 'IFN' named entity 'qPCR' named entity 'virus replication' named entity 'DMEM' named entity 'IFN-γ' named entity 'influenza vaccine' named entity 'LAIV' named entity 'internal control' named entity 'Qiagen' named entity 'isogenic' named entity 'RNA' named entity 'type I IFN' named entity 'Tracheal' named entity 'ISGs' named entity 'M2e' named entity 'AAALAC' named entity 'fibroblasts' named entity 'cross-reactive' named entity 'seroconversion' named entity 'seroconverted' named entity 'wildtype' named entity 'clinical symptoms' named entity 'endogenous' named entity 'virus' named entity 'virus' named entity 'avian influenza virus' named entity 'NS1' named entity 'virus' named entity 'statistically significant' named entity 'protein' named entity 'vaccination'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software