About: Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome
Creator	Zhang, Jing Yang, Jing Zeng, Mu-Sheng Murata, Takayuki Du, Shujuan Zhu, Fanxiu Cao, Pengfei Hu, Jingjin Liu, Lingzhi Lu, Jianhong Xie, Yan Xin, Shuyu Yue, Wenxing Zuo, Lielian Xie, Liu
source	Medline; PMC
abstract	Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Cyclophilin A (CYPA) is upregulated in EBV-associated nasopharyngeal carcinoma (NPC) with unknown roles. In the present approach, cytosolic CYPA was found to be bound with EBNA1 into the nucleus. The amino acid 376-459 of the EBNA1 domain was important for the binding. CYPA depletion attenuated and ectopic CYPA expression improved EBNA1 expression in EBV-positive cells. The loss of viral copy number was also accelerated by CYPA consumption in daughter cells during culture passages. Mechanistically, CYPA mediated the connection of EBNA1 with oriP (origin of EBV DNA replication) and subsequent oriP transcription, which is a key step for the initiation of EBV genome replication. Moreover, CYPA overexpression markedly antagonized the connection of EBNA1 to Ubiquitin-specific protease 7 (USP7), which is a strong host barrier with a role of inhibiting EBV genome replication. The PPIase activity of CYPA was required for the promotion of oriP transcription and antagonism with USP7. The results revealed a strategy that EBV recruited a host factor to counteract the host defense, thus facilitating its own latent genome replication. This study provides a new insight into EBV pathogenesis and potential virus-targeted therapeutics in EBV-associated NPC, in which CYPA is upregulated at all stages.
has issue date	2019-12-13(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02879
bibo:pmid	31921057
has license	cc-by
sha1sum (hex)	d3f515c47fec377ecc7f3961948916239e4e079f
schema:url	https://doi.org/10.3389/fmicb.2019.02879
resource representing a document's title	Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome
has PubMed Central identifier	PMC6923202
has PubMed identifier	31921057
schema:publication	Front Microbiol
resource representing a document's body	covid:d3f515c47fec377ecc7f3961948916239e4e079f#body_text
is schema:about of	named entity 'barrier' named entity 'domain' named entity 'viral' named entity 'subsequent' named entity 'Nuclear' named entity 'EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN' named entity 'DOMAIN' named entity 'ATTENUATED' named entity 'ESSENTIAL' named entity 'CELLS' named entity 'SUBSEQUENT' named entity 'GENOME' named entity 'MEDIATED' named entity 'PROVIDES' named entity 'ACCELERATED' named entity 'REPLICATION' named entity 'UPREGULATED' named entity 'CONNECTION' named entity 'EBV DNA' named entity 'STEP' named entity 'RESULTS' named entity 'IMPORTANT' named entity 'USP7' named entity 'TRANSCRIPTION' named entity 'LOSS OF' named entity 'PATHOGENESIS' named entity 'THERAPEUTICS' named entity 'VIRAL' named entity 'BINDING' named entity 'NASOPHARYNGEAL CARCINOMA' named entity 'UNKNOWN' named entity 'IMPROVED' named entity 'BARRIER' named entity 'STRONG' named entity 'HOST FACTOR' named entity 'EBNA1' named entity 'EXPRESSION' named entity 'POTENTIAL' named entity 'CULTURE' named entity 'IS A' named entity 'ASSOCIATED' named entity 'NUCLEUS' named entity 'INITIATION' named entity 'OVEREXPRESSION' named entity 'CYTOSOLIC' named entity 'STUDY' named entity 'VIRAL PATHOGENESIS' named entity 'VIRAL DNA' named entity 'PPIASE ACTIVITY' named entity 'INSIGHT' named entity 'PERSISTENCE' named entity 'HOST' named entity 'FACILITATING' named entity 'REVEALED' named entity 'GENOME' named entity 'BOUND' named entity 'ITS' named entity 'APPROACH' named entity 'ALL STAGES' named entity 'CYCLOPHILIN A' named entity 'LATENT' named entity 'ECTOPIC' named entity 'DNA' named entity 'COPY NUMBER' named entity 'AMINO ACID' named entity 'PROTEASE 7' named entity 'DEPLETION'

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