About: Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients
Creator	Biesbroek, Giske Bogaert, Debby Wang, Xinhui Bonten, Marc Sanders, Elisabeth Veenhoven, Reinier Wa Rossen, John Van Den Bergh, Menno Wyllie, Anne Aa De Steenhuijsen Piters, Wouter Gw Huijskens, Elisabeth Trzcin´ski, Krzysztof
Source	Medline; PMC
abstract	Bacterial pneumonia is a major cause of morbidity and mortality in elderly. We hypothesize that dysbiosis between regular residents of the upper respiratory tract (URT) microbiome, that is balance between commensals and potential pathogens, is involved in pathogen overgrowth and consequently disease. We compared oropharyngeal microbiota of elderly pneumonia patients (n=100) with healthy elderly (n=91) by 16S-rRNA-based sequencing and verified our findings in young adult pneumonia patients (n=27) and young healthy adults (n=187). Microbiota profiles differed significantly between elderly pneumonia patients and healthy elderly (PERMANOVA, P<0.0005). Highly similar differences were observed between microbiota profiles of young adult pneumonia patients and their healthy controls. Clustering resulted in 11 (sub)clusters including 95% (386/405) of samples. We observed three microbiota profiles strongly associated with pneumonia (P<0.05) and either dominated by lactobacilli (n=11), Rothia (n=51) or Streptococcus (pseudo)pneumoniae (n=42). In contrast, three other microbiota clusters (in total n=183) were correlated with health (P<0.05) and were all characterized by more diverse profiles containing higher abundances of especially Prevotella melaninogenica, Veillonella and Leptotrichia. For the remaining clusters (n=99), the association with health or disease was less clear. A decision tree model based on the relative abundance of five bacterial community members in URT microbiota showed high specificity of 95% and sensitivity of 84% (89% and 73%, respectively, after cross-validation) for differentiating pneumonia patients from healthy individuals. These results suggest that pneumonia in elderly and young adults is associated with dysbiosis of the URT microbiome with bacterial overgrowth of single species and absence of distinct anaerobic bacteria. Whether the observed microbiome changes are a cause or a consequence of the development of pneumonia or merely coincide with disease status remains a question for future research.
has issue date	2015-07-07(xsd:dateTime)
bibo:doi	10.1038/ismej.2015.99
bibo:pmid	26151645
has license	bronze-oa
sha1sum (hex)	d4c42ddd0d0d9ce2037d2cd40f991afff3408b95
schema:url	https://doi.org/10.1038/ismej.2015.99
resource representing a document's title	Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients
has PubMed Central identifier	PMC4681870
has PubMed identifier	26151645
schema:publication	The ISME Journal
resource representing a document's body	covid:d4c42ddd0d0d9ce2037d2cd40f991afff3408b95#body_text
is schema:about of	named entity 'anaerobic bacteria' named entity 'single' named entity 'dominated' named entity 'consequence' named entity 'young adults' named entity 'patients' named entity 'mortality' named entity 'young adult' covid:arg/d4c42ddd0d0d9ce2037d2cd40f991afff3408b95 named entity 'bacterial overgrowth' named entity 'patients' named entity 'major' named entity 'controls' named entity 'disease' named entity 'verified' named entity 'hypothesize' named entity 'nonmetric multidimensional scaling' named entity 'pneumonia' named entity 'pneumonia' named entity 'lactobacilli' named entity 'Haemophilus' named entity 'young adult' named entity 'LRTI' named entity 'Rothia' named entity 'pathogenesis' named entity 'Mann-Whitney U-tests' named entity 'oropharyngeal' named entity 'elderly' named entity 'abundances' named entity 'potential' named entity 'Microbiota' named entity 'model' named entity 'pneumonia' named entity 'Rothia' named entity 'pneumonia' named entity 'microbiota' named entity 'microbiota' named entity 'young adult' named entity 'microbiota' named entity 'pneumonia' named entity 'oropharyngeal' named entity 'upper respiratory tract' named entity 'microbiota' named entity 'pneumonia' named entity 'microbiome' named entity 'Dysbiosis' named entity 'elderly' named entity 'qPCR' named entity 'Nonmetric multidimensional scaling' named entity '1.03' named entity 'qPCR' named entity 'young adult' named entity 'pneumonia' named entity 'microbiota' named entity 'bacteria' named entity '95% CI' named entity 'NCBI' named entity 'Prevotella' named entity 'URT' named entity 'qPCR' named entity 'Netherlands' named entity 'OTUs' named entity 'Prevotella' named entity 'longitudinal studies' named entity 'pneumonia' named entity 'pneumonia' named entity 'Netherlands' named entity 'diagnostic accuracy' named entity 'species richness' named entity 'Prevotella'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software