About: Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology
Creator	Darcel, C
Source	Medline; PMC
abstract	The transmissible spongiform encephalopathies of domesticated animals, scrapie in-sheep and bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy are more than a scientific curiosity; under certain circumstances their impact on commercial activities can be calamitous. Knowledge of their causation and pathogenesis is still rudimentary, but many consider than an unconventional agent, the prion (a brain protein, PrP), that is not associated with nucleic acid is involved in both. Others believe that conventional viruses, which replicate by virtue of their nucleic acid-defined genes, are involved in the causation and progression of the encephalopathies but that technical problems have prevented their identification. Others postulate even more exotic causative agents. While this paper will particularly address the possibility of a viral aetiology for these diseases, it is also emphasized that our knowledge of the state of the immune system in animals with encephalopathy needs broadening. There are remarkable gaps in our knowledge of the histopathology of these diseases, particularly the nature of the characteristic vacuoles. Much further work is needed on the biochemical changes in the brain and the serum, particularly of the latter as it could lead to an additional means of recognizing clinical cases without waiting for the animal to die with subsequent examination of the brain for characteristic lesions and the presence of protease-K-resistant PrP.
has issue date	1995-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01839302
bibo:pmid	7571397
has license	no-cc
sha1sum (hex)	d4f3362e2820d61ad82b456b927b54c32b76f015
schema:url	https://doi.org/10.1007/bf01839302
resource representing a document's title	Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology
has PubMed Central identifier	PMC7088560
has PubMed identifier	7571397
schema:publication	Vet Res Commun
resource representing a document's body	covid:d4f3362e2820d61ad82b456b927b54c32b76f015#body_text
is schema:about of	named entity 'AND' named entity 'CONSIDERATION' named entity 'AETIOLOGY' named entity 'POSSIBILITY OF' named entity 'VETERINARY' named entity 'VIRAL' named entity 'VIRAL' named entity 'SCRAPIE' named entity 'DISCUSSION PAPER' named entity 'RELATED' named entity 'CONSIDERATION' named entity 'DISORDERS' named entity 'RELATED' named entity 'AETIOLOGY' named entity '231' named entity 'RESEARCH' named entity 'DISORDERS' named entity '283' named entity 'COMMUNICATIONS' named entity 'POSSIBILITY OF' named entity 'SCRAPIE' named entity 'hypersensitivity' named entity 'protein' named entity 'antibody' named entity 'copper' named entity 'vacuoles' named entity 'PrPSc' named entity 'CJD' named entity 'laboratory animals' named entity 'immunosuppression' named entity 'ruminant' named entity 'haemoglobin' named entity 'endogenous' named entity 'haemoglobin' named entity 'Prion protein' named entity 'RNA virus' named entity 'infection' named entity 'bovidae' named entity 'Shinagawa' named entity 'Scrapie' named entity 'virus infections' named entity 'kDa' named entity 'oncogenes' named entity 'BSE' named entity 'pruritus' named entity 'scrapie' named entity 'cattle' named entity 'Kuru' named entity 'cattle' named entity 'latent period' named entity 'ecotropic' named entity 'bovids' named entity 'paralysis' named entity 'pathognomonic' named entity 'Gajdusek' named entity 'peroxidation' named entity 'transmissible encephalopathies' named entity 'viruses' named entity 'hydrocephalus' named entity 'scrapie' named entity 'scrapie' named entity 'scrapie' named entity 'viruses' named entity 'serology' named entity 'Antibodies' named entity 'scrapie' named entity 'goat' named entity 'scrapie' named entity 'chimpanzee' named entity 'Guinea-pigs' named entity 'Syrian hamster' named entity 'bovine spongiform encephalopathy' named entity 'albumin' named entity 'spongiform encephalopathies' named entity 'BSE' named entity 'pathology' named entity 'sheep' named entity 'sheep' named entity 'virus' named entity 'scrapie' named entity 'amyloidogenic'

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