About: Structural and Functional Characterization of Gene Products Encoded in the Human Genome by Homology Detection

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About: Structural and Functional Characterization of Gene Products Encoded in the Human Genome by Homology Detection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural and Functional Characterization of Gene Products Encoded in the Human Genome by Homology Detection
Creator	Balaji, S Pandit, S Srinivasan, N
Source	PMC
abstract	Availability of the human genome data has enabled the exploration of a huge amount of biological information encoded in it. There are extensive ongoing experimental efforts to understand the biological functions of the gene products encoded in the human genome. However, computational analysis can aid immensely in the interpretation of biological function by associating known functional/structural domains to the human proteins. In this article we have discussed the implications of such associations. The association of structural domains to human proteins could help in prioritizing the targets for structure determination in the structural genomics initiatives. The protein kinase family is one of the most frequently occurring protein domain families in the human proteome while P‐loop hydrolase, which comprises many GTPases and ATPases, is a highly represented superfamily. Using the superfamily relationships between families of unknown and known structures we could increase structural information content of the human genome by about 5%. We could also make new associations of domain families to 33 human proteins that are potentially linked to genetically inherited diseases. IUBMB Life, 56: 317‐331, 2004
has issue date	2008-01-03(xsd:dateTime)
bibo:doi	10.1080/15216540400006105
bibo:pmid	15370880
has license	no-cc
sha1sum (hex)	d75c77c90a84a92ed84548dfdfa4ae2dcc1689bf
schema:url	https://doi.org/10.1080/15216540400006105
resource representing a document's title	Structural and Functional Characterization of Gene Products Encoded in the Human Genome by Homology Detection
has PubMed Central identifier	PMC7165581
has PubMed identifier	15370880
schema:publication	IUBMB Life
resource representing a document's body	covid:d75c77c90a84a92ed84548dfdfa4ae2dcc1689bf#body_text
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