About: Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice

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About: Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice
Creator	Taneichi, Maiko Uchida, Tetsuya Hayashi, Hidenori Kobayashi, Akiharu Kohyama, Shunsuke Matsui, Masanori Mori, Masahito Ohno, Satoshi Akatsuka, Toshitaka Moriya, Osamu Oda, Hiroshi
source	Elsevier; Medline; PMC
abstract	Abstract We investigated whether the surface-linked liposomal peptide was applicable to a vaccine based on cytotoxic T lymphocytes (CTLs) against severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). We first identified four HLA-A0201-restricted CTL epitopes derived from SARS-CoV using HLA-A0201 transgenic mice and recombinant adenovirus expressing predicted epitopes. These peptides were coupled to the surface of liposomes, and inoculated into mice. Two of the liposomal peptides were effective for peptide-specific CTL induction, and one of them was efficient for the clearance of vaccinia virus expressing epitopes of SARS-CoV, suggesting that the surface-linked liposomal peptide might offer an effective CTL-based vaccine against SARS.
has issue date	2009-06-12(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2009.04.001
bibo:pmid	19490987
has license	els-covid
sha1sum (hex)	d783f56cc0176b2a634a6c4e8a2679fda162acd5
schema:url	https://doi.org/10.1016/j.vaccine.2009.04.001
resource representing a document's title	Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice
has PubMed Central identifier	PMC7115666
has PubMed identifier	19490987
schema:publication	Vaccine
resource representing a document's body	covid:d783f56cc0176b2a634a6c4e8a2679fda162acd5#body_text
is schema:about of	named entity 'VIRAL CLEARANCE' named entity 'SARS-CoV' named entity 'These' named entity 'liposomes' named entity 'transgenic mice' named entity 'induce' named entity 'PEPTIDES' named entity 'RESTRICTED' named entity 'HLA-A' named entity 'THESE' named entity 'SARS' named entity 'PEPTIDE' named entity 'VACCINE' named entity 'SPECIFIC' named entity 'COUPLED' named entity 'IDENTIFIED' named entity 'VACCINIA VIRUS' named entity 'EPITOPES' named entity 'SURFACE' named entity 'MICE' named entity 'PREDICTED' named entity 'CTL' named entity 'RECOMBINANT ADENOVIRUS' named entity 'ONE OF' covid:arg/d783f56cc0176b2a634a6c4e8a2679fda162acd5 named entity 'SPECIFIC' named entity 'T LYMPHOCYTES' named entity 'LIPOSOMES' named entity 'SARS-COV' named entity 'T LYMPHOCYTES' named entity 'CORONAVIRUS' named entity 'EFFECTIVE' named entity 'CLEARANCE' named entity 'TRANSGENIC MICE' named entity 'LIPOSOMES' named entity 'HLA-A' named entity 'SURFACE' named entity 'SARS CORONAVIRUS' named entity 'EFFICIENT' named entity 'CYTOTOXIC' named entity 'OFFER' named entity 'COUPLED' named entity 'SYNTHETIC PEPTIDES' named entity 'INVESTIGATED' named entity 'LIPOSOMAL' named entity 'BASED' named entity 'DERIVED' named entity 'APPLICABLE' named entity 'INDUCTION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'USING' named entity 'INDUCE' named entity 'CYTOTOXIC' named entity 'TRANSGENIC MICE' named entity 'HLA-A' named entity 'predicted' named entity 'liposomes' named entity 'inoculated' named entity 'investigated' named entity 'peptides' named entity 'cytotoxic T lymphocytes' named entity 'SARS' named entity 'severe acute respiratory syndrome' named entity 'liposomal' named entity 'HLA-A' named entity '293 cells' named entity 'tumor' named entity 'peptides' named entity 'protein' named entity 'mice' named entity 'SARS-CoV'

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