About: Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection

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About: Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection
Creator	Sandström, Eric Schmitt, Corinna Ernberg, Ingemar Grützmeier, Sven Porwit, Anna
Source	PMC
abstract	BACKGROUND: Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues adjacent to the tumour in Burkitt lymphoma patients. Here we present a patient with asymptomatic HIV infection, that contracted a primary cytomegalovirus (CMV) infection and human herpes virus 8 (HHV-8) infection. Three weeks before onset of symptoms the patient had unprotected sex which could be possible source of his CMV and also HHV-8 infection He deteriorated rapidly and died with a generalized anaplastic large cell lymphoma (ALCL). METHODS: A Caucasian homosexual male with asymptomatic human immunodeficiency virus (HIV) infection contracted a primary cytomegalovirus (CMV) infection and human herpes virus 8 (HHV-8) infection. He deteriorated rapidly and died with a generalized anaplastic large cell lymphoma (ALCL). Clinical and laboratory records were compiled. Immunohistochemistry was performed on lymphoid tissues, a liver biopsy, a bone marrow aspirate and the spleen during the illness and at autopsy. Serology and PCR for HIV, CMV, EBV, HHV-1–3 and 6–8 was performed on blood drawn during the course of disease. RESULTS: The patient presented with an acute primary CMV infection. Biopsies taken 2 weeks before death showed a small focus of ALCL in one lymph node of the neck. Autopsy demonstrated a massive infiltration of ALCL in lymph nodes, liver, spleen and bone marrow. Blood samples confirmed primary CMV- infection, a HHV-8 infection together with reactivation of Epstein- Barr-virus (EBV). CONCLUSION: Primary CMV-infection and concomitant HHV-8 infection correlated with reactivation of EBV. We propose that these two viruses influenced the development and progression of the lymphoma. Quantitative PCR blood analysis for EBV, CMV and HHV-8 could be valuable in diagnosis and treatment of this type of very rapidly developing lymphoma. It is also a reminder of the importance of prevention and prophylaxis of several infections by having protected sex.
has issue date	2016-08-22(xsd:dateTime)
bibo:doi	10.1186/s13027-016-0094-5
bibo:pmid	27551290
has license	cc-by
sha1sum (hex)	d87b9206395dd973e9c17b32af6962ce13acf977
schema:url	https://doi.org/10.1186/s13027-016-0094-5
resource representing a document's title	Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection
has PubMed Central identifier	PMC4992999
has PubMed identifier	27551290
schema:publication	Infect Agent Cancer
resource representing a document's body	covid:d87b9206395dd973e9c17b32af6962ce13acf977#body_text
is schema:about of	named entity 'human immunodeficiency virus (HIV)' named entity 'demonstrated' named entity 'samples' named entity 'unprotected sex' named entity 'bone marrow aspirate' named entity 'disease' named entity 'bone marrow' named entity 'Most' named entity 'asymptomatic' named entity 'ALCL' named entity 'presented' named entity 'caused' named entity 'primary' named entity 'Fulminant' named entity 'anaplastic large cell lymphoma' named entity 'SEROLOGY' named entity 'HAVE' named entity 'CONTRACTED' named entity 'infection' named entity 'contracted' named entity 'HHV-1' named entity 'lymph node' named entity 'tumour' named entity 'anaplastic large cell lymphoma' named entity 'Immunohistochemistry' named entity 'laboratory' named entity 'focus' named entity 'infection' named entity 'blood' named entity 'Background' named entity 'records' named entity 'onset' named entity 'Some' named entity 'lymphoma' named entity 'asymptomatic' named entity 'ALCL' named entity 'CMV infection' named entity 'Biopsies' named entity 'HIV' named entity 'HHV-8' named entity 'lymphomas' named entity 'CMV' named entity 'CMV' named entity 'infection' named entity 'HIV' named entity 'human herpes virus 8' named entity 'HHV-8' named entity 'Blood samples' named entity 'CMV' named entity 'bone marrow' named entity 'spleen' named entity 'CMV' named entity 'Immunohistochemistry' named entity 'lymph nodes' named entity 'CMV' named entity 'HIV' named entity 'cytomegalovirus (CMV) infection' named entity 'EBV' named entity 'infection' named entity 'infection' named entity 'EBV' named entity 'serology' named entity 'PEL' named entity 'Liver enzymes' named entity 'inflammation' named entity 'Castleman's disease' named entity 'liver' named entity '1, 2' named entity 'plasma' named entity 'Bone Marrow Transplantation' named entity 'tuberculosis' named entity 'lymphoma' named entity 'VZV' named entity 'opportunistic infection' named entity 'herpes virus' named entity 'CD4 cell' named entity 'viruses'

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