About: Can extreme MHC class I diversity be a feature of a wide geographic range? The example of Seba’s short-tailed bat (Carollia perspicillata)

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Can extreme MHC class I diversity be a feature of a wide geographic range? The example of Seba’s short-tailed bat (Carollia perspicillata) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Can extreme MHC class I diversity be a feature of a wide geographic range? The example of Seba’s short-tailed bat (Carollia perspicillata)
Creator	Tschapka, Marco Sommer, Simone Qurkhuli, Tamar Schwensow, Nina Dominik Brändel, Stefan
source	Medline; PMC
abstract	The major histocompatibility complex (MHC) is one of the most diverse genetic regions under pathogen-driven selection because of its central role in antigen binding and immunity. The highest MHC variability, both in terms of the number of individual alleles and gene copies, has so far been found in passerine birds; this is probably attributable to passerine adaptation to both a wide geographic range and a diverse array of habitats. If extraordinary high MHC variation and duplication rates are adaptive features under selection during the evolution of ecologically and taxonomically diverse species, then similarly diverse MHC architectures should be found in bats. Bats are an extremely species-rich mammalian group that is globally widely distributed. Many bat species roost in multitudinous groups and have high contact rates with pathogens, conspecifics, and allospecifics. We have characterized the MHC class I diversity in 116 Panamanian Seba’s short-tailed bats (Carollia perspicillata), a widely distributed, generalist, neotropical species. We have detected a remarkable individual and population-level diversity of MHC class I genes, with between seven and 22 alleles and a unique genotype in each individual. This diversity is comparable with that reported in passerine birds and, in both taxonomic groups, further variability has evolved through length polymorphisms. Our findings support the hypothesis that, for species with a geographically broader range, high MHC class I variability is particularly adaptive. Investigation of the details of the underlying adaptive processes and the role of the high MHC diversity in pathogen resistance are important next steps for a better understanding of the role of bats in viral evolution and as carriers of several deadly zoonotic viruses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00251-019-01128-7) contains supplementary material, which is available to authorized users.
has issue date	2019-09-13(xsd:dateTime)
bibo:doi	10.1007/s00251-019-01128-7
bibo:pmid	31520134
has license	no-cc
sha1sum (hex)	d88b5306619ec217f8be41b0e634cece731fa4f3
schema:url	https://doi.org/10.1007/s00251-019-01128-7
resource representing a document's title	Can extreme MHC class I diversity be a feature of a wide geographic range? The example of Seba’s short-tailed bat (Carollia perspicillata)
has PubMed Central identifier	PMC7079943
has PubMed identifier	31520134
schema:publication	Immunogenetics
resource representing a document's body	covid:d88b5306619ec217f8be41b0e634cece731fa4f3#body_text
is schema:about of	named entity 'SEBA' named entity 'bats' named entity 'carriers' named entity 'Panamanian' named entity 'adaptive' named entity 'high' named entity 'major histocompatibility complex (MHC)' named entity 'antigen' named entity 'viral evolution' named entity 'passerine' named entity 'TAILED' named entity 'PATHOGENS' named entity 'POPULATION' named entity 'ANTIGEN BINDING' named entity 'PANAMANIAN' named entity 'FAR' named entity 'UNDERSTANDING' named entity 'GENERALIST' named entity 'DETECTED' named entity 'RANGE' named entity 'COPIES' named entity 'GROUP' named entity '116' named entity 'RICH' named entity 'NUMBER OF' named entity 'LEVEL' named entity 'REPORTED' named entity 'ATTRIBUTABLE' named entity 'ARRAY' named entity 'HABITATS' named entity 'VARIATION' named entity 'GENOTYPE' named entity 'GENE' named entity 'ALLELES' named entity 'SPECIES' named entity 'SEBA' named entity 'EVOLUTION' named entity 'MHC CLASS I' named entity 'GLOBALLY' named entity 'VIRUSES' named entity 'INVESTIGATION' named entity 'PROBABLY' named entity 'ITS' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'VARIABILITY' named entity 'BAT' named entity 'ADAPTATION' named entity 'MHC CLASS I GENES' named entity 'STEPS' named entity 'DRIVEN' named entity 'DISTRIBUTED' named entity 'MHC CLASS I' named entity 'FINDINGS' named entity 'EXTREMELY' named entity 'SHORT' named entity 'ZOONOTIC' named entity '27S' named entity 'ROOST' named entity 'ONE OF' named entity 'FEATURES' named entity 'GENETIC' named entity 'DIVERSITY' named entity 'HIGHEST' named entity 'WIDE' named entity 'MAMMALIAN' named entity 'RATES' named entity 'ADAPTIVE' named entity 'HIGH' named entity 'REGIONS' named entity 'SUPPORT' named entity 'EVOLVED' named entity 'PATHOGEN' named entity 'DUPLICATION' named entity 'GEOGRAPHIC RANGE' named entity '27S' named entity 'SHORT' named entity 'EXAMPLE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software