About: Suppression of MHV3 virus-activated macrophages by dieldrin

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Suppression of MHV3 virus-activated macrophages by dieldrin
Creator	Bernier, Jacques Fournier, Michel Hugo, Patrice Krzystyniak, Krzysztof
Source	Elsevier; Medline; PMC
abstract	Abstract Dieldrin (36 mg/kg body weight) administered intraperitoneally prolonged recovery from infection with mouse hepatitis virus 3 (MHV3) in the genetically-resistant A/J strain, affected the humoral anti-MHV3 IgG immune response, and inhibited the intrinsic antiviral activity of peritoneal macrophages upon in vitro rechallenge with the virus. Infection of untreated A/J animals and vehicle controls with MHV3 resulted in marked and reproducible activation of peritoneal macrophages, observed in vitro as resistance to MHV3-cytopathic effects 48 hr after rechallenge with the virus, whereas exposure to dieldrin resulted in apparent loss of the intrinsic capacity of cells to restrict replication of MHV3 and to protect them from cytolysis. In addition, in vitro treatment of MHV3 virus-activated macrophages with dieldrin, mitomycin C and X-irradiation, inhibited the intrinsic capacity of cells to restrict MHV3 replication. This mechanism of cellular restriction of the virus by MHV3-activated macrophages from the resistant A/J strain appeared to be one of the sensitive targets for the suppressive action of dieldrin on host resistance, as (i) no major changes in macrophage cellular parameters were observed in in vitro studies of cell viability, adherence to plastic, and Superoxide anion generation; (ii) the increased cell yield in the peritoneal exudates during MHV3 virus infection was not affected by dieldrin exposure; and (iii) the attachment and uptake of [3H]MHV3 by virus-activated macophages was shown to be unchanged by dieldrin exposure.
has issue date	1986-08-01(xsd:dateTime)
bibo:doi	10.1016/0006-2952(86)90056-0
bibo:pmid	3017357
has license	els-covid
sha1sum (hex)	d9d3627bd3e93877a8934f06db472f3d641bbc99
schema:url	https://doi.org/10.1016/0006-2952%2886%2990056-0
resource representing a document's title	Suppression of MHV3 virus-activated macrophages by dieldrin
has PubMed Central identifier	PMC7111090
has PubMed identifier	3017357
schema:publication	Biochemical Pharmacology
resource representing a document's body	covid:d9d3627bd3e93877a8934f06db472f3d641bbc99#body_text
is schema:about of	named entity 'SUPPRESSION' named entity 'observed' named entity 'macrophages' named entity 'cells' named entity 'restriction' named entity 'inhibited' named entity 'observed' named entity 'reproducible' named entity 'effects' named entity 'mechanism' named entity 'EXPOSURE TO DIELDRIN' named entity 'VIRUS' named entity 'HOST RESISTANCE' named entity 'EXUDATES' named entity 'MG%' named entity 'ADHERENCE' named entity 'MACROPHAGE' named entity 'MOUSE HEPATITIS VIRUS' named entity 'SUPPRESSIVE' named entity 'AFFECTED' named entity 'CELL' named entity 'CELLULAR' named entity 'CELLS' named entity 'CYTOPATHIC EFFECTS' named entity 'ADDITION' named entity 'MARKED' named entity 'TARGETS' named entity 'UPTAKE' named entity 'DIELDRIN' named entity 'ACTIVATED' named entity 'INCREASED' named entity 'PERITONEAL MACROPHAGES' named entity 'MAJOR' named entity 'STRAIN' named entity 'ACTIVATED MACROPHAGES' named entity 'PARAMETERS' named entity 'MITOMYCIN C' named entity 'UNTREATED' named entity 'UNCHANGED' named entity 'APPARENT' named entity 'LOSS OF' named entity 'CAPACITY' named entity 'IRRADIATION' named entity 'IGG' named entity 'VIRUS' named entity 'BODY WEIGHT' named entity 'ACTION' named entity 'RESISTANT' named entity 'ATTACHMENT' named entity 'DIELDRIN ' named entity 'CELL VIABILITY' named entity 'OBSERVED' named entity 'RECHALLENGE' named entity 'INTRINSIC' named entity 'YIELD' named entity 'CHANGES' named entity 'IN VITRO STUDIES' named entity 'PERITONEAL' named entity 'INHIBITED' named entity 'ACTIVATION' named entity 'VEHICLE' named entity 'PROLONGED' named entity 'VIRUS INFECTION' named entity 'RESTRICT' named entity 'PLASTIC' named entity 'ACTIVATED MACROPHAGES' named entity 'SENSITIVE' named entity 'ANIMALS' named entity 'MECHANISM' named entity 'ANTIVIRAL ACTIVITY' named entity 'ADMINISTERED' named entity 'REPLICATION' named entity 'DIELDRIN' named entity 'RESISTANCE TO' named entity 'IMMUNE RESPONSE' named entity 'SUPEROXIDE ANION GENERATION' named entity 'IN VITRO' named entity '28I'

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