About: Emergence of a group 3 coronavirus through recombination

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About: Emergence of a group 3 coronavirus through recombination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Emergence of a group 3 coronavirus through recombination
Creator	Jackwood, Mark Boynton, Tye Byrd, Lauren Hilt, Deborah Jackwood, Joshua Kissinger, Jessica Lemke, Conelia Mccall, Amber Mckinley, Enid Paterson, Andrew Robertson, Jon Williams, Susan
source	Elsevier; Medline; PMC
abstract	Abstract Analyses of turkey coronavirus (TCoV), an enteric disease virus that is highly similar to infectious bronchitis virus (IBV) an upper-respiratory tract disease virus in chickens, were conducted to determine the adaptive potential, and genetic changes associated with emergence of this group 3 coronavirus. Strains of TCoV that were pathogenic in poults and nonpathogenic in chickens did not adapt to cause disease in chickens. Comparative genomics revealed two recombination sites that replaced the spike gene in IBV with an unidentified sequence likely from another coronavirus, resulting in cross-species transmission and a pathogenicity shift. Following emergence in turkeys, TCoV diverged to different serotypes through the accumulation of mutations within spike. This is the first evidence that recombination can directly lead to the emergence of new coronaviruses and new coronaviral diseases, emphasizing the importance of limiting exposure to reservoirs of coronaviruses that can serve as a source of genetic material for emerging viruses.
has issue date	2010-03-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.11.044
bibo:pmid	20022075
has license	els-covid
sha1sum (hex)	da9b5bfef894c4b497e24567c8505897f34df5f1
schema:url	https://doi.org/10.1016/j.virol.2009.11.044
resource representing a document's title	Emergence of a group 3 coronavirus through recombination
has PubMed Central identifier	PMC7111905
has PubMed identifier	20022075
schema:publication	Virology
resource representing a document's body	covid:da9b5bfef894c4b497e24567c8505897f34df5f1#body_text
is schema:about of	named entity 'RECOMBINATION' named entity 'virus' named entity 'This' named entity 'sequence' named entity 'genetic material' named entity 'PATHOGENICITY' named entity 'CORONAVIRUSES' named entity 'FOLLOWING' named entity 'CHICKENS' named entity 'SPIKE' named entity 'NEW' named entity 'DISEASES' named entity 'ENTERIC' named entity 'GROUP 3' named entity 'RESPIRATORY TRACT DISEASE' named entity 'CROSS' named entity 'TO CAUSE DISEASE' named entity 'GENETIC MATERIAL' named entity 'MUTATIONS' named entity 'RESULTING IN' named entity 'CORONAVIRUS' named entity 'UPPER' named entity 'SHIFT' named entity 'REVEALED' named entity 'ACCUMULATION' named entity 'LEAD' named entity 'EXPOSURE TO' named entity 'EMERGENCE' named entity 'A GROUP' named entity 'COMPARATIVE GENOMICS' named entity 'REPLACED' named entity 'VIRUSES' named entity 'TURKEYS' named entity 'CORONAVIRUS' named entity 'TURKEY CORONAVIRUS' named entity 'RESERVOIRS' named entity 'RECOMBINATION' named entity 'DETERMINE' named entity 'ASSOCIATED WITH' named entity 'SEROTYPES' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'POTENTIAL' named entity 'DIRECTLY' named entity 'UNIDENTIFIED' named entity 'LIMITING' named entity 'SEQUENCE' named entity 'GROUP 3' named entity 'SERVE' named entity 'SOURCE' named entity 'DISEASE VIRUS' named entity 'CHANGES' named entity 'TRANSMISSION' named entity 'DIFFERENT' named entity 'EVIDENCE' named entity 'LIKELY' named entity 'GENE' named entity 'ADAPT' named entity 'SIMILAR' named entity 'GENETIC' named entity 'STRAINS' named entity 'DID' named entity 'ADAPTIVE' named entity 'HIGHLY' named entity 'SPECIES' named entity 'PATHOGENIC' named entity 'EMERGENCE' named entity 'SITES' covid:arg/da9b5bfef894c4b497e24567c8505897f34df5f1 named entity 'spike' named entity 'emergence'

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