About: Persistence of rhinovirus RNA and IP‐10 gene expression after acute asthma

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Persistence of rhinovirus RNA and IP‐10 gene expression after acute asthma
Creator	Grissell, Terry Powell, Heather Gibson, Peter Hensley, Michael Shafren, Darren Wood, Lisa Davies, Bronwyn Whitehead, Bruce
Source	Medline; PMC
abstract	Background and objective: Viral nucleic acid may be detected for up to 6 months after an acute asthma deterioration, but the pattern and consequences of viral persistence after acute asthma are incompletely understood. This study investigates the frequency of viral persistence after acute asthma, assesses viral infectivity and determines the host inflammatory responses to viral persistence. Methods: Adults and children presenting to hospital with acute asthma and a confirmed respiratory virus infection were studied acutely and at recovery 4–6 weeks later by clinical evaluation and induced sputum for viral and inflammatory mediator detection. Results: Viral RNA was detected during both acute asthma and recovery visits in 17 subjects (viral persistence), whereas in 22 subjects viral RNA had cleared by recovery (viral clearance). The following viruses were detected at recovery: human rhinovirus: 16; respiratory syncytial virus: 2; influenza: 2. In subjects with viral persistence, eight isolates were different to the virus detected at Visit 1. Forty‐four per cent of the human rhinovirus isolates were infective at recovery. Asthma and infection severity were similar in the viral clearance and viral persistence groups. Viral persistence was associated with elevated IL‐10 mRNA and inducible protein‐10 gene expression. Conclusions: Respiratory viral detection after acute asthma is common, and most often persistence is with non‐infective human rhinovirus. There is a host inflammatory response with an altered cytokine environment, and the viral RNA can be source of persistent infection. These effects may have longer‐term consequences in asthma.
has issue date	2011-01-27(xsd:dateTime)
bibo:doi	10.1111/j.1440-1843.2010.01897.x
bibo:pmid	21054674
has license	no-cc
sha1sum (hex)	daab92fad58903ca8634a6f01e7df806427903ba
schema:url	https://doi.org/10.1111/j.1440-1843.2010.01897.x
resource representing a document's title	Persistence of rhinovirus RNA and IP‐10 gene expression after acute asthma
has PubMed Central identifier	PMC7192211
has PubMed identifier	21054674
schema:publication	Respirology
resource representing a document's body	covid:daab92fad58903ca8634a6f01e7df806427903ba#body_text
is schema:about of	named entity 'confirmed' named entity 'infectivity' named entity 'detection' named entity 'asthma' named entity 'frequency' named entity 'inflammatory mediator' named entity 'induced' named entity 'recovery' named entity 'rhinovirus' named entity 'sputum' named entity 'inflammatory responses' named entity 'infectivity' named entity 'nucleic acid' named entity 'RNA' named entity 'IP-10' named entity 'SSPE' named entity 'asthma' named entity 'virus' named entity 'HRV' named entity 'virus' named entity 'asthma exacerbation' named entity 'viral infection' named entity 'HRV' named entity 'IL-8' named entity 'virus' named entity 'non-parametric' named entity 'lungs' named entity 'viral replication' named entity 'expression analysis' named entity 'HRV' named entity 'viral persistence' named entity 'cytokines' named entity 'Asthma exacerbation' named entity 'Viral persistence' named entity 'asthmatic' named entity 'defence mechanisms' named entity 'HRV' named entity 'PCR' named entity 'viral infections' named entity 'viral persistence' named entity 'epithelium' named entity 'virus' named entity 'gene expression' named entity 'asymptomatic' named entity 'sputum' named entity 'PCR' named entity 'infection' named entity 'IL-10' named entity 'acute asthma' named entity 'viral RNA' named entity 'virus' named entity 'cytolytic' named entity 'Emergency Department' named entity 'viral mutations' named entity 'HEp-2' named entity 'infection' named entity 'virus infection' named entity 'HRV' named entity 'gene expression' named entity 'Wilcoxon rank sum test' named entity 'epithelial cell' named entity 'antibodies' named entity 'host cell' named entity 'RNA' named entity 'Germany' named entity 'acute exacerbation' named entity 'sputum' named entity 'nebulization' named entity 'apoptosis' named entity 'gene expression' named entity 'HRV' named entity 'HRV' named entity 'infection' named entity 'Gel Extraction'

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