About: The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females

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About: The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females
Creator	Wang, Yuanyuan Zhao, Jun Zhang, Yue Zhang, Xu Wang, Bei Dai, Qiaoyun Guan, Ting He, Wenshan Hu, Xuhuai Ma, Xu Peng, Zuoqi Qi, Daxun Yang, Xueying Zhang, Hongguang
source	PMC
abstract	The relationship between females with low glucose-6-phosphate dehydrogenase activity level (LG6PD) and HBV infection is unclear. We conducted a cross sectional study of 124 406 reproductive-age Chinese females who participated in the National Free Pre-conception Check-up Projects to investigate the risk of HBV infection among females with LG6PD and its effect on liver enzyme. Based on HBV serological test results, the participants were divided into the susceptible, immunized, and HBV infected groups. The multivariable-adjusted odds ratios (ORs) for HBV infection in LG6PD participants were 1.71 (95% confidence interval (CI): 1.45–2.01) and 1.41 (95% CI: 1.23–1.62), respectively with the susceptible and immunized participants as references, compared to those without LG6PD. Participants with HBV infection only and combined with HBV infection and LG6PD had 184% and 249% significantly higher risks of elevated alanine transaminase (ALT) (susceptible participants as reference). If the immunized participants were used as reference, significant higher odds of elevated ALT occurred (3.48 (95% CI: 3.18–3.80), 4.28 (95% CI: 2.92–6.28)). Thus, reproductive-age females with LG6PD had a higher prevalence of HBV infection, and LG6PD might exacerbate ALT elevation in HBV infected females. Our findings underscore the need to explore collaborative management approaches for these two diseases among reproductive-age females for maternal and child health.
has issue date	2019-03-07(xsd:dateTime)
bibo:doi	10.1038/s41598-019-40354-7
bibo:pmid	30846733
has license	cc-by
sha1sum (hex)	db0c5eb977ace3792bd9796c78e4d7e6bc243a7e
schema:url	https://doi.org/10.1038/s41598-019-40354-7
resource representing a document's title	The association between low glucose-6-phosphate dehydrogenase activity level and hepatitis B virus infection among pre-pregnant reproductive-age Chinese females
has PubMed Central identifier	PMC6405931
has PubMed identifier	30846733
schema:publication	Sci Rep
resource representing a document's body	covid:db0c5eb977ace3792bd9796c78e4d7e6bc243a7e#body_text
is schema:about of	named entity 'ORs' named entity 'maternal' named entity 'Our' named entity 'susceptible' named entity 'Projects' named entity 'infection' named entity 'hepatitis B virus' named entity 'SUSCEPTIBLE' named entity 'IMMUNIZED' named entity 'ALANINE TRANSAMINASE' named entity 'ELEVATED ALT' named entity 'DISEASES' named entity 'INFECTION ONLY' named entity 'RELATIONSHIP' named entity 'COMPARED' named entity 'ELEVATED' named entity 'CONFIDENCE INTERVAL' named entity 'LIVER ENZYME' named entity 'THESE' named entity 'AGE' named entity 'ITS' named entity 'HBV INFECTION' named entity 'SIGNIFICANT' named entity 'ALT' named entity 'APPROACHES' named entity 'LOW GLUCOSE' named entity 'USED' named entity 'UNCLEAR' named entity 'MATERNAL AND CHILD HEALTH' named entity 'PRE' named entity 'NEED' named entity 'DIVIDED' named entity 'TO INVESTIGATE' named entity '184' named entity 'FEMALES' named entity 'INFECTED' named entity 'FINDINGS' named entity 'ELEVATION' named entity 'EXACERBATE' named entity 'CHECK-UP' named entity 'RISKS' named entity 'OCCURRED' named entity 'PREGNANT' named entity 'SEROLOGICAL TEST' named entity 'GROUPS' named entity 'RISK OF' named entity 'FREE' named entity 'FEMALES' named entity 'REPRODUCTIVE' named entity 'LOW GLUCOSE' named entity 'COLLABORATIVE' named entity 'OPEN' named entity 'CHINESE' named entity 'PRE' named entity 'HEPATITIS B VIRUS INFECTION' named entity 'ACTIVITY LEVEL' named entity 'ADJUSTED' named entity '124' named entity 'PREVALENCE' named entity 'CONCEPTION' named entity 'COMBINED' named entity 'PARTICIPANTS' named entity 'HIGHER' named entity '80%' named entity 'GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY' named entity 'ODDS' named entity 'ACTIVITY LEVEL' named entity 'EFFECT'

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