About: A biomimetic platelet based on assembling peptides initiates artificial coagulation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A biomimetic platelet based on assembling peptides initiates artificial coagulation
Creator	Li, Yuan Wang, Lei Wang, Hao Zhang, Kuo Fan, Yu Gao, Xingfa Gao, Xuejiao Chen, Zi-Ming Cheng, Dong-Bing He, Ping-Ping Hou, Da-Yong Shi, Linqi Yang, Pei-Pei Yi, Yu Zhang, Jing-Ping Zhang, Xian-Zheng
source	Medline; PMC
abstract	Platelets play a critical role in the regulation of coagulation, one of the essential processes in life, attracting great attention. However, mimicking platelets for in vivo artificial coagulation is still a great challenge due to the complexity of the process. Here, we design platelet-like nanoparticles (pNPs) based on self-assembled peptides that initiate coagulation and form clots in blood vessels. The pNPs first bind specifically to a membrane glycoprotein (i.e., CD105) overexpressed on angiogenetic endothelial cells in the tumor site and simultaneously transform into activated platelet-like nanofibers (apNFs) through ligand-receptor interactions. Next, the apNFs expose more binding sites and recruit and activate additional pNPs, forming artificial clots in both phantom and animal models. The pNPs are proven to be safe in mice without systemic coagulation. The self-assembling peptides mimic platelets and achieve artificial coagulation in vivo, thus providing a promising therapeutic strategy for tumors.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1126/sciadv.aaz4107
bibo:pmid	32766439
has license	cc-by-nc
sha1sum (hex)	dbc3e501470d5744307bb54e05b8c9006ce14470
schema:url	https://doi.org/10.1126/sciadv.aaz4107
resource representing a document's title	A biomimetic platelet based on assembling peptides initiates artificial coagulation
has PubMed Central identifier	PMC7385434
has PubMed identifier	32766439
schema:publication	Sci Adv
resource representing a document's body	covid:dbc3e501470d5744307bb54e05b8c9006ce14470#body_text
is schema:about of	named entity 'vivo' named entity 'nanofibers' named entity 'animal models' named entity 'peptides' named entity 'self-assembling' named entity 'phantom' named entity 'coagulation' named entity 'binding sites' named entity 'artificial' named entity 'activated' named entity 'attention' named entity 'peptides' named entity 'Next' named entity 'strategy' named entity 'therapeutic' named entity 'peptides' named entity 'self-assembling' named entity 'coagulation' named entity 'ligand' named entity 'binding sites' named entity 'platelet' named entity 'Cy3' named entity 'cell lines' named entity 'coagulation' named entity 'NPs' named entity 'fluorescence' named entity 'incubation' named entity 'coagulation' named entity 'tumor' named entity 'endoglin' named entity 'breast cancer' named entity 'molecule' named entity 'umbilical vein' named entity 'monomers' named entity 'tumor' named entity 'fluorescence' named entity 'biocompatibility' named entity 'peptide' named entity 'plasma' named entity 'liposomes' named entity 'tumors' named entity 'particulate' named entity 'DMSO' named entity 'filter paper' named entity 'nude mice' named entity 'confocal laser scanning microscopy' named entity 'IgG' named entity 'conjugated' named entity 'multispectral optoacoustic tomography' named entity 'RBCs' named entity 'peptide synthesis' named entity 'HUVECs' named entity 'mice' named entity 'pyrenes' named entity 'Chinese Academy of Medical Sciences' named entity 'tumor' named entity 'CD105' named entity 'ultraviolet-visible absorption' named entity 'NPs' named entity 'coagulation process' named entity 'dehydrated' named entity 'CD105' named entity 'morphology' named entity 'CD105' named entity 'monomer' named entity 'pH 8'

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