About: Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion

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About: Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion
Creator	Zhang, Ling Wu, Ying Cheng, Anchun Wang, Mingshu Chen, Shun Jia, Renyong Sun, Di Chen, Xiaoyue Liu, Mafeng Yang, Qiao Zhu, Dekang Xu, Zhiwen Tian, Bin Liu, Yunya Mao, Sai Yu, Yanling Zhang, Shaqiu Chen, Zhengli Luo, Qihui Wang, Yin Zhao, Xin-Xin Huang, Juan He, Tianqiong Zhu, Lin Ou, Xuming Pan, Leichang Rehman, Mujeeb
Source	Medline; PMC
abstract	BACKGROUND: Host shutoff refers to the widespread downregulation of host gene expression and has emerged as a key process that facilitates the reallocation of cellular resources for viral replication and evasion of host antiviral immune responses. MAIN BODY: The Herpesviridae family uses a number of proteins that are responsible for host shutoff by directly targeting messenger RNA (mRNA), including virion host shutoff (VHS) protein and the immediate-early regulatory protein ICP27 of herpes simplex virus types 1 (HSV-1) and the SOX (shutoff and exonuclease) protein and its homologs in Gammaherpesvirinae subfamilies, although these proteins are not homologous. In this review, we highlight evidence that host shutoff is promoted by the VHS, ICP27 and SOX-like proteins and that they also contribute to immune evasion. CONCLUSIONS: Further studies regarding the host shutoff proteins will not only contribute to provide new insights into the viral replication, expression and host immune evasion process, but also provide new molecular targets for the development of antiviral drugs and therapies.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1186/s12985-020-01336-8
bibo:pmid	32430029
has license	cc-by
sha1sum (hex)	dc3c5dbf46d5ade28305dc7da15655e1972c8ee9
schema:url	https://doi.org/10.1186/s12985-020-01336-8
resource representing a document's title	Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion
has PubMed Central identifier	PMC7235440
has PubMed identifier	32430029
schema:publication	Virol J
resource representing a document's body	covid:dc3c5dbf46d5ade28305dc7da15655e1972c8ee9#body_text
is schema:about of	named entity 'cellular' named entity 'Host' named entity 'types' named entity 'targeting' named entity 'facilitates' named entity 'downregulation' named entity 'host' named entity 'VHS' named entity 'survival' named entity 'targets' named entity 'provide' named entity 'homologous' named entity 'proteins' named entity 'host' named entity 'antiviral drugs' named entity 'protein' named entity 'regulatory protein' named entity 'viral replication' named entity 'homologous' named entity 'VHS' named entity 'protein' named entity 'spliced mRNAs' named entity 'cell membrane' named entity 'gammaherpesvirus' named entity 'EBV' named entity 'CD1d' named entity 'exonuclease activity' named entity 'IFN' named entity 'IFI16' named entity 'translation initiation' named entity 'misfolded proteins' named entity 'PKR' named entity 'VHS' named entity 'RNase' named entity 'inflammation' named entity 'sumoylation' named entity 'viral infection' named entity 'DNA and RNA' named entity 'innate immune' named entity 'IL-6' named entity 'mRNA degradation' named entity 'EMCV' named entity 'immune response' named entity 'protein' named entity 'STING' named entity 'substrates' named entity 'viruses' named entity 'viral proteins' named entity 'host defense' named entity 'cytokines' named entity 'betaherpesviruses' named entity 'VHS' named entity 'mRNA' named entity 'VHS' named entity 'mRNAs'

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