About: Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway

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About: Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway
Creator	Li, Yongjun Chen, Zhi Huang, Chenjie Shi, Yixian Wu, Haicong Xue, Jihua Yang, Zhenggang Ying, Lixiong
topic	covid:dd2a154b5fe59f997e47913b3a6da5d23bdb7556#this
Source	Medline; PMC
abstract	The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment of the metabolic disorders. However, the impact of RSV on HBV replication remains unknown. In this study, the HBV-expressing hepatocelluar carcinoma cell line and mouse model created by hydrodynamic injection of viral DNA were used. We found that RSV activates Sirt1, which in turn deacetylates PGC-1α and subsequently increases the transcriptional activity of PPARα, leading to the enhanced HBV transcription and replication in vitro and in vivo. In addition, we found that this pathway is also required for fasting-induced HBV transcription. Taken together, this study identifies that RSV enhances HBV transcription and replication especially acting on the core promoter, which depends on Sirt1-PGC-1α-PPARα pathway. We conclude that RSV may exacerbate the progression of hepatitis B and that patients with hepatitis B infection should be cautious taking RSV as a dietary supplement.
has issue date	2016-04-21(xsd:dateTime)
bibo:doi	10.1038/srep24744
bibo:pmid	27098390
has license	cc-by
sha1sum (hex)	dd2a154b5fe59f997e47913b3a6da5d23bdb7556
schema:url	https://doi.org/10.1038/srep24744
resource representing a document's title	Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway
has PubMed Central identifier	PMC4838842
has PubMed identifier	27098390
schema:publication	Sci Rep
resource representing a document's body	covid:dd2a154b5fe59f997e47913b3a6da5d23bdb7556#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/dd2a154b5fe59f997e47913b3a6da5d23bdb7556
is schema:about of	named entity 'METABOLIC DISORDERS' named entity 'HEPATITIS B' named entity 'PROGRESSION' named entity 'HBV' named entity 'UNKNOWN' named entity 'LEADING' named entity 'MOUSE MODEL' named entity 'TAKING' named entity 'PPAR' named entity 'STUDY' named entity 'PATHWAY' named entity 'TREATMENT' named entity 'viral' named entity 'metabolic disorders' named entity 'Sirt1' named entity 'Resveratrol' named entity 'REPLICATION' named entity 'DRUG' named entity 'CARCINOMA CELL LINE' named entity 'USED' named entity 'INJECTION' named entity 'CREATED BY' named entity 'RSV' named entity 'VIRAL DNA' named entity 'CONCLUDE' named entity 'IMPACT' named entity 'HYDRODYNAMIC' named entity 'ENHANCED' named entity 'PATIENTS' named entity 'EXACERBATE' named entity 'TRANSCRIPTIONAL ACTIVITY' named entity 'TRANSCRIPTION' named entity 'SIRT1' named entity 'ACTIVATING' named entity 'OPEN' named entity 'PGC-1' named entity 'RESVERATROL' named entity 'HBV' named entity 'PATHWAY' named entity 'PPAR' named entity 'SIRT1' named entity 'NUMBER OF' named entity 'PRECLINICAL' named entity 'TAKEN' named entity 'FOUND' named entity 'ACTIVATES' named entity 'ADDITION' named entity 'IN VIVO' named entity 'REQUIRED' named entity 'REPLICATION' named entity 'INCREASES' named entity 'COMBINED' named entity 'RESVERATROL' named entity 'CORE PROMOTER' named entity 'POPULATION' named entity 'INCREASING' named entity 'PGC-1' named entity 'DIETARY SUPPLEMENT' named entity 'IN VITRO' named entity 'TURN' covid:arg/dd2a154b5fe59f997e47913b3a6da5d23bdb7556 named entity 'drug' named entity 'DNA' named entity 'transcription' named entity 'HBV' named entity 'HBV' named entity 'PPARα' named entity 'transcriptional activity' named entity 'carcinoma' named entity 'PPARα' named entity 'carcinoma' named entity 'RSV'

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