About: Human choline dehydrogenase: Medical promises and biochemical challenges

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human choline dehydrogenase: Medical promises and biochemical challenges
Creator	Gadda, Giovanni Salvi, Francesca
source	Elsevier; Medline; PMC
abstract	Abstract Human choline dehydrogenase (CHD) is located in the inner membrane of mitochondria primarily in liver and kidney and catalyzes the oxidation of choline to glycine betaine. Its physiological role is to regulate the concentrations of choline and glycine betaine in the blood and cells. Choline is important for regulation of gene expression, the biosynthesis of lipoproteins and membrane phospholipids and for the biosynthesis of the neurotransmitter acetylcholine; glycine betaine plays important roles as a primary intracellular osmoprotectant and as methyl donor for the biosynthesis of methionine from homocysteine, a required step for the synthesis of the ubiquitous methyl donor S-adenosyl methionine. Recently, CHD has generated considerable medical attention due to its association with various human pathologies, including male infertility, homocysteinuria, breast cancer and metabolic syndrome. Despite the renewed interest, the biochemical characterization of the enzyme has lagged behind due to difficulties in the obtainment of purified, active and stable enzyme. This review article summarizes the medical relevance and the physiological roles of human CHD, highlights the biochemical knowledge on the enzyme, and provides an analysis based on the comparison of the protein sequence with that of bacterial choline oxidase, for which structural and biochemical information is available.
has issue date	2013-09-15(xsd:dateTime)
bibo:doi	10.1016/j.abb.2013.07.018
bibo:pmid	23906661
has license	els-covid
sha1sum (hex)	de0de0b319aef66d29785a987b54683fb7126db8
schema:url	https://doi.org/10.1016/j.abb.2013.07.018
resource representing a document's title	Human choline dehydrogenase: Medical promises and biochemical challenges
has PubMed Central identifier	PMC7094428
has PubMed identifier	23906661
schema:publication	Archives of Biochemistry and Biophysics
resource representing a document's body	covid:de0de0b319aef66d29785a987b54683fb7126db8#body_text
is schema:about of	named entity 'BLOOD' named entity 'LIVER' named entity 'GLYCINE BETAINE' named entity 'MEMBRANE' named entity 'INNER MEMBRANE' named entity 'HOMOCYSTEINE' named entity 'CONCENTRATIONS' named entity 'BIOCHEMICAL' named entity 'MEDICAL' named entity 'PHOSPHOLIPIDS' named entity 'RELEVANCE' named entity 'BIOCHEMICAL CHARACTERIZATION' named entity 'SYNTHESIS' named entity 'INTEREST' named entity 'ANALYSIS' named entity 'ACETYLCHOLINE' named entity 'IMPORTANT' named entity 'ENZYME' named entity 'METHYL' named entity 'PROVIDES' named entity 'pathologies' named entity 'enzyme' named entity 'catalyzes' named entity 'medical' named entity 'HUMAN' named entity 'INFORMATION' named entity 'REQUIRED' named entity 'PLAYS' named entity 'LOCATED IN' named entity 'ACTIVE' named entity 'NEUROTRANSMITTER' named entity 'BASED' named entity 'INCLUDING' named entity 'MITOCHONDRIA' named entity 'BIOCHEMICAL' named entity 'BIOSYNTHESIS OF METHIONINE' named entity 'ROLES' named entity 'AVAILABLE' named entity 'BIOSYNTHESIS' named entity 'PRIMARY' named entity 'METABOLIC SYNDROME' named entity 'VARIOUS' named entity 'DONOR' named entity 'ARTICLE' named entity 'PROTEIN SEQUENCE' named entity 'MEDICAL' named entity 'CHOLINE DEHYDROGENASE' named entity 'CHALLENGES' named entity 'OXIDATION' named entity 'REVIEW' named entity 'MALE INFERTILITY' named entity 'LIPOPROTEINS' named entity 'ASSOCIATION' named entity 'REGULATION OF GENE EXPRESSION' named entity 'S-ADENOSYL METHIONINE' named entity 'KIDNEY' named entity 'PHYSIOLOGICAL' named entity 'BREAST CANCER' named entity 'BACTERIAL' named entity 'CHD' named entity 'INTRACELLULAR' named entity 'PHYSIOLOGICAL ROLE' named entity 'CHOLINE DEHYDROGENASE' named entity 'TO REGULATE' named entity 'CHOLINE' named entity 'HUMAN' named entity 'KNOWLEDGE' named entity 'STEP' named entity 'DUE TO' named entity 'PATHOLOGIES' named entity 'PURIFIED' named entity 'CONSIDERABLE' named entity 'COMPARISON' named entity 'STRUCTURAL' named entity 'CELLS' named entity 'CHOLINE OXIDASE' named entity 'ATTENTION' named entity 'ITS' named entity 'STABLE' named entity 'DIFFICULTIES'

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