About: Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity

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About: Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity
Creator	Balzarini, Jan Liekens, Sandra Noppen, Sam Mathys, Leen Cavada, Benildo Gondim, Ana Li, Rsc Medchemcomm, / Nagano, Celso Nascimento, Kyria Renata, Cintia Roberta Da Silva, Suzete Rocha, Costa Sadler, Peter Sampaio, Alexandre
Source	PMC
abstract	Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: Canavalia brasiliensis (ConBr), C. maritima (ConM), Dioclea lasiocarpa (DLasiL) and D. sclerocarpa (DSclerL), and algae Amansia multifida (AML), Bryothamniom seaforthii (BSL), Hypnea musciformis (HML), Meristiella echinocarpa (MEL) and Solieria filiformis (SfL). They were exposed to a panel of 18 different viruses, including HIV and influenza viruses. Several lectins showed highly potent antiviral activity, often within the low nanomolar range. DSclerL and DLasiL exhibited EC(50) values (effective concentration of lectin required to inhibit virus-induced cytopathicity by 50%) of 9 nM to 46 nM for HIV-1 and respiratory syncytial virus (RSV), respectively, DLasiL also inhibited feline corona virus at an EC(50) of 5 nM, and DSclerL, ConBr and ConM showed remarkably low EC(50) values ranging from 0.4 to 6 nM against influenza A virus strain H3N2 and influenza B virus. For HIV, evidence pointed to the blockage of entry of the virus into its target cells as the underlying mechanism of antiviral action of these lectins. Overall, the most promising lectins based on their EC(50) values were DLasiL, DSclerL, ConBr, ConM, SfL and HML. These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential.
has issue date	2019-01-14(xsd:dateTime)
bibo:doi	10.1039/c8md00508g
bibo:pmid	30996857
has license	cc-by
sha1sum (hex)	de9f765a9c35d3ea9c4423235277d69e6bab1823
schema:url	https://doi.org/10.1039/c8md00508g
resource representing a document's title	Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity
has PubMed Central identifier	PMC6430086
has PubMed identifier	30996857
schema:publication	Medchemcomm
resource representing a document's body	covid:de9f765a9c35d3ea9c4423235277d69e6bab1823#body_text
is schema:about of	named entity 'BIODIVERSITY' named entity 'LECTINS' named entity '80%' named entity 'panel' named entity 'influenza B virus' named entity 'lectins' named entity 'Med' named entity 'lead' named entity 'CARBOHYDRATE' named entity 'SFL' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'EXPOSED TO' named entity 'TREAT' named entity 'THERAPEUTIC' named entity 'HIGHLY' named entity 'AMANSIA MULTIFIDA' named entity 'BLOCKAGE' named entity '0.4' named entity 'DIFFERENT' named entity 'H3N2' named entity 'HERE' named entity 'INCLUDING' named entity 'ONE OF' named entity 'MED' named entity 'SOLIERIA FILIFORMIS' named entity 'LECTIN' named entity 'NORTHEASTERN' named entity '10%' named entity 'FELINE' named entity 'BRAZIL' named entity 'SPECIES' named entity 'POTENTIAL' named entity 'DISEASES' named entity 'ANTIVIRAL ACTIVITY' named entity 'VALUES' named entity 'CANAVALIA BRASILIENSIS' named entity 'HYPNEA MUSCIFORMIS' named entity 'MECHANISM' named entity 'UNDERLYING' named entity 'CONCENTRATION OF' named entity 'HIV' named entity 'HIV-1' named entity 'ITS' named entity 'HML' named entity 'MERISTIELLA' named entity 'INFLUENZA B VIRUS' named entity 'HAVE' named entity 'NEW' named entity 'BRAZILIAN' named entity 'BRAZILIAN' named entity 'ALGAL' named entity 'INFLUENZA A VIRUS' named entity 'SEARCH' named entity 'VIRUS' named entity 'FLORA' named entity 'LEAD' named entity 'NOVEL' named entity 'CHEM' named entity 'TARGET CELLS' named entity 'STRAIN' named entity 'THEIR' named entity 'PURIFIED' named entity 'SPECIFIC' named entity 'EXTRACTED' named entity 'INVESTIGATED' named entity 'POINTED' named entity 'LARGEST'

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